氨来呫诺抑制树突细胞成熟及对实验性自身免疫性脑脊髓炎保护作用的研究

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1、授予单位代码10089学号或申请号20151052中国图书分类号R744.5HebeiMedicalUniversity博士学位论文学术学位氨来呫诺抑制树突细胞成熟及对实验性自身免疫性脑脊髓炎保护作用的研究研究生：全墨缘导师：郭力教授专业：神经病学二级学院：第二医院2018年4月目录中文摘要·········································································································

2、·1英文摘要··········································································································7英文缩写··········································································································13研究论文氨来呫诺抑制树突细胞成熟及对实验性自身免疫性

3、脑脊髓炎保护作用的研究引言··········································································································15第一部分氨来呫诺抑制骨髓来源树突细胞表型及功能成熟并且可能同TBK1/Akt通路相关前言······················································································

4、····················17材料与方法······························································································19结果··········································································································26附图················

5、··························································································30讨论··········································································································33小结···············································

6、···························································35参考文献··································································································36第二部分氨来呫诺通过抑制Th1/Th17细胞及其炎症因子改善实验性自身免疫性脑脊髓炎病情前言········································

7、··································································39材料与方法······························································································40结果················································································

8、··························53附图··········································································································56讨论·······································································································