血清脂质代谢谱在慢加急性肝衰竭患者早期诊断及预测预后中的应用

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1、授予单位代码10089学号或申请号20153143中国图书分类号R575.3HebeiMedicalUniversity硕士学位论文专业学位血清脂质代谢谱在慢加急性肝衰竭患者早期诊断及预测预后中的应用研究生：张梦晨导师：姜慧卿教授专业：内科学二级学院：河北医科大学第二医院2018年3月目录中文摘要········································································································10英文摘要······························

2、··········································································20英文缩写········································································································40研究论文血清脂质代谢谱在慢加急性肝衰竭患者早期诊断及预测预后中的应用前言···································································

3、·····································50材料与方法······························································································60结果········································································································70附表·······································

4、·································································90附图········································································································12讨论········································································································14结论····

5、····································································································16参考文献·································································································26综述血清脂质代谢谱在肝衰竭疾病中的研究进展·································19致谢··························

6、··············································································30个人简历········································································································31中文摘要血清脂质代谢谱在慢加急性肝衰竭患者早期诊断及预测预后中的应用摘要目的：肝脏是脂代谢的主要部位，脂代谢紊乱是晚期肝硬化及肝衰竭患者常见的并发症之一，早期诊断能够降低慢加急性肝衰竭（acute-

7、on-chronicliverfailure，ACLF）患者病死率。本研究旨在探讨血清脂质代谢谱与肝硬化患者严重程度的关系及在ACLF患者早期诊断及预测预后中的作用。方法：纳入297例肝硬化患者，其中Child-PughA(CA组)103例、Child-PughB(CB组)104例、Child-PughC(CC组)90例以及64例ACLF患者。检测所有患者血脂水平及相关临床指标，并评估其与疾病严重程度及肝硬化患者发生ACLF的关系。结果：ACLF患者胆固醇(CHOL)、高密度脂蛋白胆固醇(HDL)、载脂蛋白A(apoA)水平显