低分子肝素治疗早发型妊娠期子痫的效果评价

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1、低分子肝素治疗早发型妊娠期子痫的效果评价许艳萍翁世湘黄水英吴汉姬惠东县妇幼保健院妇科惠州市中心人民医院妇科摘要：目的探讨妊娠期妇女应用低分子肝素（LMW11）的效果及安全性。方法选取2010-2014年医院收治的早发型子痫前期患者135例作为研宂对象，随机分为观察组68例和对照组67例，观察组应用低分子肝素联合硫酸镁进行治疗，对照组釆用硫酸镁进行治疗。观察两组患者的血压变化、APTT值、妊娠结局、新牛JL情况等来判断两组方法的临床疗效，记录并进行比较。结果两组患者血压较治疗前均有显著下降;APTT值观察组（37.3±2.8）s与对照组（35.3±2.7）s比较差笄有统计学意义（P

2、<0.01）:观察组患荠尿蛋白好转率41.18%优于对照组的23.88%,差异有统计学意义（P<0.05）:孕妇常见妊娠并发症的发生率两组差异无统计学意义（P〉0.05）。观察组新生儿体质量（1547.50±309.56）g与对照组（1542.26±522.51）g差异无统计学意义（P〉0.05）。结论应用低分子肝素预防妊娠期妇女子痫，取得丫较好的临床效果，安全有效丑不良反应较少，值得临床进一步推广研宄。关键词：低分了肝素;硫酸镁;早发型了痫前期;Effectivenessevaluationoflowmolecularweightheparinintreatmentofearl

3、y-onsetpreeclampsiaXUYan-PingWENGShi-XiangHUANGShui—YingDepartmentofGynecology,HuidongCountyMaternalandChildHealthCareHospital;Abstract：ObjectiveToexploretheeffectandsafetyoflowmolecularweightheparin(LMWH)inpregnantwomen.MethodsAtotalof135patientswithearly-onsetpreeclampsiatreatedinHuidongCou

4、ntyMaternalandChildHealthCareHospitalfrom2010to2014wereselected，thentheyweredividedintoobservationgroup(68patients)andcontrolgroup(67patients)randomly.ThepatientsinobservationgroupweretreatedbyLMWHcombinedwithmagnesiumsulfate,andthepatientsincontrolgroupweretreatedbymagnesiumsulfate.Thechange

5、sofbloodpressure,activatedpartialthromboplastintime(APTT)，pregnancyoutcomes,neonatalsituationsinthetwogroupswereobservedtopredicttheclinicaleffects,theresultswererecordedandcompared.ResultsThelevelsofbloodpressureinthetwogroupsaftertreatmentweresignificantlylowerthanthosebeforetreatment.APTTi

6、nobservationgroupandcontrolgroupwere(37.3+2.8)sand(35.3±2.7)s，respectively,therewasstatisticallysignificantdifferencebetweenthetwogroups(P〈0.01).Theimprovementrateofurineproteininobservationgroupwas41.18%，whichwasstatisticallysignificantlyhigherthanthatincontrolgroup(23.88%)(P<0.05).Therewasn

7、ostatisticallysignificantdifferenceintheincidenceratesofpregnancycomplicationsbetweenthetwogroups(P>0.05).Neonatalweightsinobservationgroupandcontrolgroupwere(1547.50±309.56)gand(1542.26±522.51)g,respectively,therewasnostatisticallysignifican