尿酸与脑梗死相关性研究进展

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1、授予单位代码10089学号或申请号20153227中国图书分类号R743HebeiMedicalUniversity硕士学位论文专业学位尿酸与脑梗死相关性研究进展研究生：胡长阔导师：郭书英教授专业：神经病学二级学院：河北医科大学第二医院2018年3月目录中文摘要············································································································1英文摘要····························

2、················································································2英文缩写············································································································3综述尿酸与脑梗死相关性研究进展····························································4致谢

3、··················································································································19个人简历··········································································································20中文摘要尿酸与脑梗死相关性研究进展摘要脑梗死的发病率、死亡率、致残率极高给社会家庭带来巨

4、大的负担。然而，脑梗死的发病、治疗及预后等方面仍然存在很多未知环节。尿酸是嘌呤分解代谢的终产物，在脑梗死的发病过程中血清尿酸水平扮演着很重要的角色。但临床上关于尿酸和脑梗死的关系却颇有争议。一些研究发现高尿酸不但和高血压、糖尿病、动脉粥样硬化、房颤并存可能导致脑梗死的发生，而且可作为脑梗死预后的标志物。高尿酸血症是脑梗死最重要的危险因素之一。早期检测、干预血清尿酸进行降尿酸治疗，也许可以预防脑梗死，降低脑梗死发病率及致残率。然而，其他研究表明，急性脑梗死后血尿酸水平升高有神经保护作用。现就近年来脑梗死与尿酸的关系作一综述。关键词：尿酸，脑

5、梗死，糖尿病，高血压，动脉粥样硬化，房颤，阿司匹林抵抗1英文摘要ResearchprogressonthecorrelationbetweenuricacidandcerebralinfarctionABSTRACTThehighincidence,mortality,anddisabilityrateofcerebralinfarctionbringahugeburdentothesocialandfamily.However,therearestillmanyunknownaspectsoftheincidence,treatment

6、andprognosisofcerebralinfarction.Uricacidistheendproductofpurinecatabolism.Itplaysanimportantroleintheprocessofcerebralinfarction.Butinclinicaltherelationshipbetweenuricacidandcerebralinfarctioniscontroverted.Someresearchfoundthathyperuricemianotonlycoexistswithhypertensi

7、on,diabetes,atherosclerosisandatrialfibrillationwhichmayleadtocerebralinfarction,butalsoasamarkerofprognosisofcerebralinfarction.Hyperuricemiaisoneofthemostimportantriskfactorofcerebralinfarction.Theexaminationsandinterventionofserumuricacidmaypreventcerebralinfarctionear

8、ly,andreducemorbidityanddisability.Howeverotherstudiesdemonstratedthatthereareneuroprotectiveeff