氟哌啶醇的结构解析

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1、Haloperidol药物名称：氟哌啶醇化学名：1-（4-氟苯基）_4-（4-（4-氯苯基）-4-羟基-1-哌啶基〕-1-丁酮结构式：CII适应症：①各种急、慢性精神分裂症。②焦虑性神经症。③儿童抽动-秽语综合征，乂称TOureUe综合征（TS）,小剂量木品治疗有效，能消除不自主的运动，又能减轻和消除伴存的精神症状。④呕吐及顽固性呃逆。SDBS-MassSDBS—MassMS-IW-9284SUBSNO.140244—(4—C.p—cKloropKenyl)-4—Kydroxypiperidino)-4—£luorobutyropKenon

2、eC21H23CLF1I02(Masso£molecularion：375)1OO150200250m/zxllsssaAIPPy300SourceTemperature:170°CSampleTemperature：:180°CDIRECT,75eVIRHIT—HO番7189

3、5C0REwIJ1SOBS一MO^1冬024

4、IR一N丨DA—613兮2;KBRD3SC4<4-(P-CHLOROPHENYLI-4-HYOROXYPIPERIDINO1-4•-FLUOROBU7YROPHEMONCtooI3M4MOKOOO3129GS29^857

5、2955•M2917GO2fi39422fl2437169241401M?JI4&6Ml17299216244Gs45I3G939I3L4S7l?SS，5l?44I23S3Q12241*91199吻3use1211312SlJ104710874?10

6、pipexidino)—4*luorobutyrophenone160140120loo80604020198.074381126.5610008167.15114F2115.59468E9162.15121F2115.17482F9149.01446369.3655710133.82231F457.1141411133.76223F448.7378512130.75488F537.6380013130.56773F535.5245714621.8842515127.489757JHNMRII7I54ISDBS-^NMRSDBSNo.140

7、24HSP-43-188c21h23Clfn024-(4-(p-chlorophenyl)—4-hydroxypiperidino)-4"-fluorobutyrophenone9ClHAssign.Shift(ppm)A8.085G2.582B本l7.37J2.360C7.36K2.34D7.34Ll.85lE4.85Ml.674E2.982Nl.476Shift(ppm)Assign.J(F-l9,A)=5.6HZJ(F-l9,C):9.0HZ