抗生素英文课件精品_1

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1、ANTIBIOTICSPresentedbyDr.Pavankumar.GP.G.STUDENTCONTENTSTERMINOLOGYHISTORYOFANTIBIOTICSRATIONALEOFDRUGUSEPATTERNSOFMISUSEDRUGLEGISLATIONSCLASSIFICATIONOFAMA’SBACTERIALGROWTHCURVEMODUSOPERANDIOFAMA’SPRINCIPLESOFANTIBIOTICDOSINGDRUGRESISTANCESULFONAMIDESCOTRI

2、MOXAZOLEFLOUROQUINOLONESCEPHALOSPORINSCHLORAMPHENICOLAMINOGLYCOSIDESMACROLIDESMISCELLANEOUSANTIBIOTICSANTIFUNGALS&ANTIVIRALDRUGSPENICILLINSTETRACYCLINESMETRONIDAZOLEANTIBIOTICFAILURESNON-EFFECTIVECONDITIONSINDENTISTRYNEWERANTI-MICROBIALAPPROACHESANTIBIOMABI

3、BILOGRAPHYPHARMACOLOGY&THERAPEUTICSFORDENTISTRY---Yagiela.Dowd.Neidle5theditionESSENTIALSOFMEDICALPHARMACOLOGY---K.D.Tripathi5theditionTEXTBOOKOFMICROBIOLOGY---R.Ananthanarayan&C.K.J.PanikerORAL&MAXILLOFACIALINFECTIONS---Topazian4theditionMICROBIOLOGYANINTR

4、ODUCTION---Tortora,Funke,Case8theditionTERMINOLOGYANTIBIOTICS--Substancesproducedbymicroorganismswhichsuppressthegrowthoforkillothermicroorganismsatverylowconcentrations.ANTIMICROBIALAGENTS–SubstancesproducedsyntheticallyaswellAsnaturallyobtaineddrugsthatat

5、tenuatemicroorganisms.CHEMOTHERAPY–Treatmentofsystemicinfectionswithspecificdrugsthatselectivelysuppresstheinfectingmicroorganismswithoutsignificantlyaffectingthehost.DRUG–Singleactivechemicalentitypresentinmedicinethatisusedfordiagnosis,prevention,treatmen

6、t/cureofadisease.HISTORYPERIODOFEMPIRICALUSEUseofmouldycurdbychineseonboilsChaulmoograoilbyhindusinleprosyChenopodiumbyaztecsforintestinalwormsMercurybyparacelsusforsyphilisCinchonabarkforfeversEHRLICH’SPHASEOFDYES&ORGANOMETALLICS(1890-1935)Ifdyescouldselec

7、tivelystainmicrobes,theycouldbeselectivelytoxicalso.Atoxylforsleepingsickness.Arsphenamine&norarsphenamineforsyphilisEHRLICHalsocoinedtheterm“Chemotherapy”.MODERNERAItwasin1929thatALEXANDERFLEMINGbyserendipityelaboratedpenicillinfromthemouldofP.notatum.DOMA

8、GKin1935demonstratedthetherapeuticeffectofPRONTOSILasulfonamidedye.Butitwasfrom1939-41whenCHAIN&FLOREYcarriedonthestudiesofFlemingwhichculminatedintheuseofpenicillins.In1940’sWAKSMAN&colleaguesdevelope