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1、Applyinga4Dmultiscaleinvivotumorgrowthmodeltotheexplorationofradiotherapyscheduling:Theeffectsofweekendtreatmentgapsandp53genestatusontheresponseoffastgrowingsolidtumorsDimitraD.Dionysiou1,2andGeorgiosS.Stamatakos11InSilicoOncologyGroup,LaboratoryofMicrowavesandFiberOptics,I
2、nstituteofCommunicationandComputerSystems,SchoolofElectricalandComputerEngineering,NationalTechnicalUniversityofAthens,GR-15780Zografos,Greece2DepartmentofMathematics,SchoolofAppliedSciences,NationalTechnicalUniversityofAthens,GR-15780Zografos,GreeceCorrespondence:Dr.Georgio
3、sStamatakos,InSilicoOncologyGroup,LaboratoryofMicrowavesandFiberOptics,InstituteofCommunicationandComputerSystems,SchoolofElectricalandComputerEngineering,NationalTechnicalUniversityofAthens,GR-15780Zografos,Greece.Tel:+302107722288,Fax:+302107723557,Email:gestam@central.ntu
4、a.gr.Thisarticleisanopen-accessarticledistributedunderthetermsandconditionsoftheCreativeCommonsAttributionlicense(http://creativecommons.org/licenses/by/3.0/).ThisarticlehasbeencitedbyotherarticlesinPMC.ABSTRACTThepresentpaperaimsatdemonstratingclinicallyorientedapplications
5、ofthemultiscalefourdimensionalinvivotumorgrowthsimulationmodelpreviouslydevelopedbyourresearchgroup.Tothisendtheeffectofweekendradiotherapytreatmentgapsandp53genestatusontwovirtualglioblastomatumorsdifferingonlyinp53genestatusisinvestigatedinsilico.Tumorresponsepredictionsco
6、ncerningtworatherextremedosefractionationschedules(dailydoseof4.5Gyadministeredin3equalfractions)namelyHART(HyperfractionatedAcceleratedRadiotherapyweekendless)54GyandCHART(ContinuousHART)54Gyarepresentedandcompared.Themodelpredictionssuggestthat,forthesamep53status,HART54Gy
7、andCHART54Gyhavealmostthesamelongtermeffectsonlocoregionaltumorcontrol.However,nodatahavebeenlocatedintheliteratureconcerningacomparisonofHARTandCHARTradiotherapyschedulesforglioblastoma.Asnonsmallcelllungcarcinoma(NSCLC)mayalsobeafastgrowingandradiosensitivetumor,acompariso
8、nofthemodelpredictionswiththeoutcomeofclinicalstudiesconcerningtheresponseo
