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1、Applyinga4Dmultiscaleinvivotumorgrowthmodeltotheexplorationofradiotherapyscheduling:Theeffectsofweekendtreatmentgapsandp53genestatusontheresponseoffastgrowingsolidtumorsDimitraD.Dionysiou1,2andGeorgiosS.Stamatakos11InSilicoOncologyGroup,LaboratoryofMicrowavesandFiberOptics,InstituteofCommunicatio
2、nandComputerSystems,SchoolofElectricalandComputerEngineering,NationalTechnicalUniversityofAthens,GR-15780Zografos,Greece2DepartmentofMathematics,SchoolofAppliedSciences,NationalTechnicalUniversityofAthens,GR-15780Zografos,GreeceCorrespondence:Dr.GeorgiosStamatakos,InSilicoOncologyGroup,Laboratory
3、ofMicrowavesandFiberOptics,InstituteofCommunicationandComputerSystems,SchoolofElectricalandComputerEngineering,NationalTechnicalUniversityofAthens,GR-15780Zografos,Greece.Tel:+302107722288,Fax:+302107723557,Email:gestam@central.ntua.gr.Thisarticleisanopen-accessarticledistributedunderthetermsandc
4、onditionsoftheCreativeCommonsAttributionlicense(http://creativecommons.org/licenses/by/3.0/).ThisarticlehasbeencitedbyotherarticlesinPMC.ABSTRACTThepresentpaperaimsatdemonstratingclinicallyorientedapplicationsofthemultiscalefourdimensionalinvivotumorgrowthsimulationmodelpreviouslydevelopedbyourre
5、searchgroup.Tothisendtheeffectofweekendradiotherapytreatmentgapsandp53genestatusontwovirtualglioblastomatumorsdifferingonlyinp53genestatusisinvestigatedinsilico.Tumorresponsepredictionsconcerningtworatherextremedosefractionationschedules(dailydoseof4.5Gyadministeredin3equalfractions)namelyHART(Hy
6、perfractionatedAcceleratedRadiotherapyweekendless)54GyandCHART(ContinuousHART)54Gyarepresentedandcompared.Themodelpredictionssuggestthat,forthesamep53status,HART54GyandCHART54Gyhavealmostthesamelongtermeffectsonlocoregionaltumorcontrol.However,nodatahavebeenlocatedintheliteratureconcerningacompar
7、isonofHARTandCHARTradiotherapyschedulesforglioblastoma.Asnonsmallcelllungcarcinoma(NSCLC)mayalsobeafastgrowingandradiosensitivetumor,acomparisonofthemodelpredictionswiththeoutcomeofclinicalstudiesconcerningtheresponseo
