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1、DiabetesMellitus2021/10/71BeijingXuanwuHospitalDiabetesMellitusdefinitiontypessymptomsdiagnosisLaboratoryfindingstreatmentcomplications2021/10/72BeijingXuanwuHospitalDefinition-WHO(4/2000)Thetermdiabetesmellitusdescribesametabolicdisorderofmultipleaetiologycharacteriz

2、edbychronichyperglycaemiawithdisturbancesofcarbohydrate,fatandproteinmetabolismresultingfromdefectsininsulinsecretion,insulinaction,orboth2021/10/73BeijingXuanwuHospitalDefinitionAmetabolicconditioncharacterisedbyhighplasmaglucoselevelsandchronicvascularcomplicationsA

3、vasculardiseaseaffectingsmallandlargearterieswithcoexistentmetabolicdisturbanceparticularlyhighplasmaglucoselevels2021/10/74BeijingXuanwuHospitalDiabetesMellitusdefinitiontypessymptomsdiagnosisLaboratoryfindingstreatmentcomplications2021/10/75BeijingXuanwuHospitalAeti

4、ologicalClassificationofDisordersofGlycaemiaType1(beta–celldestruction,usuallyleadingtoabsoluteinsulindeficiency):Autoimmune:IdiopathicType2(mayrangefrompredominantlyinsulinresistancewithrelativeinsulindeficiencytoapredominantlysecretorydefectwithorwithoutinsulinresis

5、tance)OtherspecifictypesGeneticdefectsofbeta–cellfunctionGeneticdefectsininsulinactionDiseasesoftheexocrinepancreasEndocrinopathiesDrug–orchemical–inducedInfectionsUncommonformsofimmune–mediateddiabetesOthergeneticsyndromessometimesassociatedwithdiabetesGestationaldia

6、betes2021/10/76BeijingXuanwuHospitalType1diabetesPreviouslyknownasIDDM(Insulindependentdiabetes)Ketosisprone:Usuallydiagnosedinyoungeragegroup(<30years)(Peakincidence11-13yr)Prevalencehighlyvariablebutapproximately0.20%withanincidenceof15-20per100000populationagedless

7、than21Seasonalvariation-withlowestrateinspringandsummer2021/10/77BeijingXuanwuHospitalType1diabetesmellitusImmune-mediatedtype1diabetesacuteLADAlatentautoimmunediabetesinadultsIdiopathictype1diabetesmellitus2021/10/78BeijingXuanwuHospitalType1diabetesmellitusGeneticsE

8、nvironmentalfactorVirusesChemicalagentsAutoimmuneAuto-antibodies:isletcellcytoplasmantibody(ICCA)isletcellsurfaceantibody(IC