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1、CORNEADISEASEPhysiologyThecorneafunctionsasaprotectivemembraneanda“window”throughwhichlightrayspasstotheretina.Itstransparencyisduetoitsuniformstructure,avascularity,anddeturgescence.Deturgescence,orthestateofrelativedehydrationofthecornealtissue,ismaintainedbytheactivebicarbonat
2、e“pump”oftheendotheliumandthebarrierfunctionoftheepitheliumandendothelium.CornealresistancetoinfectionTheepitheliumisanefficientbarriertotheentranceofmicroorganismsintothecornea.Oncetheepitheliumistraumatized,however,theavascularstromaandBowman’slayerbecomesusceptibletoinfectionw
3、ithavarietyoforganisms,includingbacteria,amebas,andfungi.PhysiologyofsymptomsSincethecorneahasmanypainfibers,mostcorneallesions,superficialordeep(cornealforeignbody,cornealabrasion,interstitialkeratitis),causepainandphotophobia.Sincethecorneaservesasthewindowoftheeyeandrefractsli
4、ghtrays,corneallesionsusuallyblurvisionsomewhat,especiallyifcentrallylocated.Photophobiainthecornealdiseaseistheresultofpainfulcontractionofaninflamediris.KeratitisKeratitis——generalintroduction§Etiologyinfectivitybacteria,fungus,virus,acanthamoebaNoinfectivityImmuneabnormal,inju
5、rylackofvitaminEndogenousorlocalspreading§varietyandoutcomeofkeratitisCornealedemaandinfiltrationCornealulcerhealing:NebulamaculaleucomaCornealperforationhealing:adherentLeucomacornealstaphylomasecondaryglaucomaCornealfistula*Endophthalmitis*panophthalmitis*atrophyofglobeKerati
6、tis——generalintroduction§ClinicalsituationsymptomsIrritativesymptomsPainPhotophobiaLacrimationBlepharospasmReducedvisualacuityKeratitis——generalintroductionsignsciliarycongestioncornealopacityedemaandinfiltrationUlcerationSecondaryIridocyclitissignsVascularizationKeratitis——gener
7、alintroductionDiagnosisClinicaldiagnosisEtiologicaldiagnosisTreatmentBasicalprincipleTogetridofthecauseofdiseasecontroltheinfectionlocalsystematicunionpromotetheulcerhealingReducethescarformationRecoverthesightKeratitis——generalintroductionBacterialkeratitisMajorbacterialfamil
8、iesStaphylococcusStreptococcusPseudomona
