急性胃肠炎病毒e课件

《急性胃肠炎病毒e课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、GastrointestinalVirusesViralGastroenteritisItisthoughtthatvirusesareresponsibleforupto3/4ofallinfectivediarrhoeas.Viralgastroenteritisisthesecondmostcommonviralillnessafterupperrespiratorytractinfection.Indevelopingcountries,viralgastroenteritisisamajorkillerofinfantswhoareundernourished.R

2、otavirusesareresponsibleforhalfamilliondeathsayear.Manydifferenttypesofvirusesarefoundinthegutbutonlysomeareassociatedwithgastroenteritis.AssociatedwithgastroenteritisRotavirusesAdenoviruses4041Caliciviruses嵌杯病毒NorwalklikevirusesorSRSV(SmallRoundStructuredViruses)AstrovirusesSRV(SmallRound

3、Viruses)CoronavirusesTorovirusesFoundinthegut,notnormallyassociatedwithgastroenteritisPolioCoxsackieACoxsackieBEchoEnteroviruses68-71HepatitisAHepatitisEAdenoviruses1-39ReovirusesFoundinthegutasopportunisticinfectionCMVHSVVZVHIVGastrointestinalVirusesVirusGenomeTypicaldiseaseincubationDura

4、tionRotaviruses:GroupA,B,Cds-segmentedRNAMajorcauseofdiarrheainchildren1-3days24-56h5-8days3-7daysCalicivirusesNorwalkagentsssRNAInfectsadultsandchildrenEpidemicviralgastroenteritis1-3days18-24h1-3days12-48hEAd40,41LineardsRNAdiarrheainchildren7-8days8-12dAstrovirus+ssRNAInfectsmainlychild

5、renandelderly1-4days1-4dGastrointestinalVirusesInfants:RotavirusA;Adenovirus40,41;CoxsackieA24virusInfants,children,andadultsNorwalkvirus;Calicivirus嵌杯病毒;astrovirus;RotavirusB;Reovirus.HumanRotavirusImportantCharacteristics70nmround,doubleshelled,enclosingagenomeof11segmentsofdoublestrande

6、dRNA.GroupsofRotavirusesGroupAsubtypes1,2,3,4(mainhumanpathogens)(Further7subtypes)alsoinfectanimals(monkey,calf,mouse)GroupBInfectspigsandratsFoundtocauseextensiveoutbreaksinChinainpastdecadeGroupCInfectsPigs(OccasionallyMan)GroupDInfectsbirdsGroupEInfectspigsPathogenesisEssentiallyanin

7、gestiondisease(faecal-oralroute)Incubationisshort:1to3daysIllness:Suddenonsetwaterydiarrhoea,withorwithoutvomiting.Maylastupto6days(orlongerifimmunocompromised).Thediseaseisselflimiting.Complications:Dehydrationmayresult,thiscanbesevereandlifethreateninginyoun