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1、BMCMusculoskeletalDisordersBioMedCentralDebateOpenAccessRolesofhyaluronaninboneresorptionCharlesWPrince*Address:WebbNutritionSciencesBuilding,Room324,DepartmentofNutritionSciences,UniversityofAlabamaatBirmingham,Birmingham,ALUSAEmail:CharlesWPrince*-princecw@uab.edu*
2、CorrespondingauthorPublished:29April2004Received:27February2004Accepted:29April2004BMCMusculoskeletalDisorders2004,5:12Thisarticleisavailablefrom:http://www.biomedcentral.com/1471-2474/5/12©2004Prince;licenseeBioMedCentralLtd.ThisisanOpenAccessarticle:verbatimcopying
3、andredistributionofthisarticlearepermittedinallmediaforanypurpose,providedthisnoticeispreservedalongwiththearticle'soriginalURL.AbstractBackground:Hyaluronan,anunsulfatedglycosaminoglycan,whilebeingcloselylinkedtoosteoclastfunctionseveralyearsago,hasreceivedlittleatt
4、entionlately.Givenrecentnewknowledgeofhyaluronan'spossiblecellbindingabilities,itisimportanttore-examinetheroleofthispolysaccharideinbonehomeostasis.Discussion:Previouslypublisheddatademonstratingalinkagebetweeninductionofhyaluronansynthesisandosteoclast-mediatedbone
5、resorptionarereviewed.Suggestionsaremadeinvolvingthecellbindingabilityofhyaluronananditspotentialtomediateosteoclastbindingtobonesurfacesanditspotentialtoserveasadiffusionbarrierandparticipateinthesealingzonerequiredforosteoclast-mediatedboneresorption.Summary:Thisbr
6、iefarticlesummarizespreviousstudieslinkingHAtoboneresorptionandsuggestsrolesforhyaluronanintheprocessofboneresorption.BackgroundLinkageofhyaluronansynthesistoboneresorptionHyaluronan(HA)isanunsulfatedglycosaminoglycanSeveralstudies[3-5]demonstratedthattreatmentinvivo
7、consistingofasinglerepeatingdisaccharideunit(1,4-glu-withparathyroidglandextract(PTE)resultedinincreasedcuronicacid-β-1,3-N-acetylglucosamine-β).HAisaboutbonesynthesisofhexosamine-containingcompound(s).1–10%ofcartilageglycosaminoglycans,butitisalsoBasedonsuchfindings
8、,Seversonetal.[6]usedorgancul-widelydistributedinothertissues,e.g.intheskin,theeye,turesofneonatalmousecalvaria,treatedwithPTEandan
