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1、HindawiPublishingCorporationInternationalJournalofPolymerScienceVolume2010,ArticleID807935,8pagesdoi:10.1155/2010/807935ResearchArticleHyaluronanImmobilizedPolyurethaneasaBloodContactingMaterialFeirongGong,YueLu,HuiGuo,ShujunCheng,andYunGaoKeyLaboratoryforU
2、ltrafineMaterialsofMinistryofEducation,SchoolofMaterialsScienceandEngineering,EastChinaUniversityofScienceandTechnology,Shanghai200237,ChinaCorrespondenceshouldbeaddressedtoShujunCheng,chshj2003@yahoo.cnReceived1March2010;Accepted16March2010AcademicEditor:Sh
3、anfengWangCopyright©2010FeirongGongetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.Hyaluronan(hyaluronicacid,HA)was
4、immobilizedontothesurfaceofamino-functionalizedpolyurethanefilmswiththegoalofobtaininganovelkindofbiomaterialwhichhadthepotentialinblood-contactingapplications.Theamino-functionalizedpolyurethanewaspreparedbysynthesizedacidicpolyurethanewhosependantcarboxylg
5、roupsweretreatedwithanexcessamountof1,3-diaminopropaneinthepresenceofN,N-carbonyldiimidazole(CDI).AttenuatedtotalreflectionFouriertransforminfraredspectroscopy(ATR-FTIR),Ramanspectroscopy(RS),scanningelectronmicroscopy(SEM),andwatercontactanglemeasurementwer
6、eusedtoconfirmthesurfacechangesateachstepoftreatment,bothinmorphologiesandchemicalcompositions.APTTandPTresultsshowedthatHAimmobilizationcouldprolongthebloodcoagulationtime,thusHA-immobilizedpolyurethane(PU-HA)exhibitedimprovedbloodcompatibility.Cytotoxicity
7、analysisshowedthatthePU-HAfilmssynthesizedinthisstudywerecytocompatibleandcouldsupporthumanveinendothelialcells(HUVECs)adhesionandproliferation.1.Introductionplateletsandbloodcelladhesionratherthanprolongthecoagulationtime.Thermoplasticpolyurethanes(PU)haveb
8、eenwidelyusedHyaluronan(HA),alinearbiopolymernaturallyabun-forvariousbiomedicalapplicationsduetotheirexcellentdantinmammaliantissues,iscomposedofrepeatingunitsmechanicalpropertiesandproperbloodcompatib
