不同比例壳聚糖胶原复合骨、软骨缺损支架材料的制备及性状比较

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1、中国组织工程研究与临床康复74眷42助2010—10—15出版JournalofClinicalRehabilitativeTissueEngineenngResearchOctober15,2010Vo1．14，No．42不同比例壳聚糖胶原复合骨、软骨缺损支架材料的制备及性状比较王九辉，未东兴，张震Preparationandcharacteristicsofchitosan—collagencompoundboneandcartilagedefectscafoldsWangJiu-hui，WeiDong·xing，Zh

2、angZhenAbstractBACKGROUND：BonetissueengineeringscafoldsdevelopsfrOmautologousbone，cartilagematerialstobioactiveceramics，DepartmentofBoneSurgery,JinzhouevenorganicmateriaIcollagenandotherextracelularmatrix，theirbiocompatibilityandperformancebecomemoreandmoreCentraI

3、Hospita1．excellent．closeto『nvivoconditions．Howeverthesematerialsneedtoimproveanti—compressionandstrengthJinzhout21go0LiaoningProvince，OBJECTIVE：Topreparebiologicalscafoldsbyadjustingtheproportionofcollagenandchitosan，totestbiologicalChinacharacteristicsandtooffera

4、graftforboneandcartilagedefect．METHODS：Chitosanandcolagenproteinweremeltedbydiferentratios．thenthematerialswerefreeze—driedafterUVWangJiu-hui．cross—linkingtopreparescafroIdsbytwicefreeze-dry．Theporosity,degradationrate，swellingratioofthescafoldsatdiferentAssociate

5、chiefphysician．proportionsweredetermined．Theparticlesizeanddistributionwereobsewedbyscanningelectronmicroscope．DepartmentofBoneRESUL．TSANDCONCLUSION：ThepreparedscafoldwasspongeandporousTheapertureofthescafoldwasnegativelySurgery．Jinzhourelatedwiththecolagencontent

6、．Thecollagenhadlessimpactontheoverallporositywiththeincreasedratioofcollagen．TheCentraIHospitat．Jinzhou121000．swellingratecanreachabout80％．swellingdegreeofthescafoldwasreducedwiththeincreasingproportionofcollagenTheLiaoningProvince，toughnessdegreeanddegradationrat

7、eincreasedwiththecollagenratioup．Thehigherchitosancontent．theslowerdegradationChinarate．Adjustingcollagenandchitosanratiocouldmakethescafoldsasasubstitutefortheboneandcartilagedefectyunshengma@transplantation．126cemReceived：201O6_23WangJH．WeiDX．ZhangZ．Preparationa

8、ndcharacteristicsofchitosan—collagencompoundboneandcartilagedefectscafoldsAccepted：2010-07—23ZhongguoZuzhiGongchengYanjiuyuLinchuangKangfu．2010；14(42)：7