壳聚糖-明胶复合网络支架体内修复兔关节软骨缺损的实验分析

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1、wasasthesameaSthatofnormalcartilagearoundthedefects．Thenewtissuecombinedwithnormalcartilagefirmlyandthethicknessissimilartothatofnonllalcartilage．WeCanseethetidallineandsubchondral．boneregeneratedtotally．InBgroupsthedefectswerealmostashighasnormalcartilageandfilledbyt

2、hehyaline_likecartilage．Butnumberofthesenewlybornchondrocytesisstillhigherthannormalcartilage．CellsaresmallinthesurfaceofthedefectsandbiggerinthedeeplamellaoftheNewtissues．Thestainingofthecartilage．specificextracellularmatrixWasasthesameasthatofnormalcartilagearoundth

3、edefects．Thenewtissuecombinedwithnormalcartilagefirmlyandthethicknessissimilartothatofnonnalcartilage．WeCanseethetidallineandsubchondral．boneregeneratedtotallv-InCgroups，thedefectswerefilledmainlybyfibrous-likecartilage，thesurfacesofwhichwereunevenandtheborderswereide

4、ntifiedclearly．Cellsinthedefectsaresmallerthanthenormalchondrocytesandhavealongandnarrowshape．Thesecellsarrayedirregular．Thestainingoftheextracellularmatrixissuperficial．Theregenerationofthetidallineandsubchondral—boneneverhappened．After8，12and16weeksoftheoperation，th

5、erewerestatisticaldifferenceamongthethreegroups(P<0．05)accordingtohistologicalgradescaleandgrayscalevalueofsafraninOstaining．andthereNOstatisticaldifferencebetweenAandBgroupsfP

6、gtechnologyisakindofnewtissueengineeringscaffoldsandhavegoodbiocompatibilityandbiodegradation．ItCansupplysuperordinarythreedimensionalstructuresforchondrocytesandisfitfordefectsofanyshapeanddepth．Chitosan—Gelatinhybridscaffoldsignificantlyacceleratetheregenerationofch

7、ondrocytesandthesecretionofECM．Itdevelopedanewwayfortlleselectionoftissueengineeringscaffold．2Deminerizedantigen-extradtedcancellous．boneseliminatetheshortagesofbadbiocompatibilityandmaterialsourcedeficit．Asatypicaltissueengineeringscaffold，ithasthreedimensionalstruct

8、ureswhichisgoodfortheadhesl’onandgenerationofchondrocytesandpromotedthesecretionofECM．Thisstudysuppor￡sthepotentialuseofDemi