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《阿糖胞苷应用与急性白血病的临床效果》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、摘要目的评价阿糖胞苷治疗急性细胞白血病的疗效。方法查阅国内外已公开发表或未发表的比较含与不同剂量阿糖胞苷治疗方案对急性白血病疗效的验文献,以血液学缓解率、中位起效时间、无病生存时间及患者不良反应情况等为评价指标,采用Cochrane协作网RevMan.0软件进行Meta分析。结果纳入3个随机对照试验,共包括70例受试对象。结果表明,使用阿糖胞苷对急性白血病患者的血液学缓解率（P<0.05),中位起效时间和无病生存时间（P<0.05），及不良反应情况（P>0.05）影响差异无统计学意义。结论根据对照实验组样本的随机对照试验结果,在急性白血病化疗方案中应
2、用阿糖胞苷有显示提高疗效的证据。目前的证据足以推荐阿糖胞苷用于急性白血病的常规化疗中。关键词：阿糖胞苷；白血病；临床效果目录locatedintheTomb,DongShenJiabang,deferthenextdayfocusedontheassassination.Linping,Zhejiang,1ofwhichliquorwinemasters(WuzhensaidinformationisCarpenter),whogotAfewbayonets,duetomissedfatal,whennightcame9宜顺论文网www.13Lw.c
3、om引言··································21.0资料与方法·························1-41.1病因和发病机制·······················21.2临床表现·····························2-31.3化疗原则·····························31.4研究对象······························31.5观察指标······························31.6治疗方案locatedint
4、heTomb,DongShenJiabang,deferthenextdayfocusedontheassassination.Linping,Zhejiang,1ofwhichliquorwinemasters(WuzhensaidinformationisCarpenter),whogotAfewbayonets,duetomissedfatal,whennightcame9宜顺论文网www.13Lw.com······························31.7疗效评价标准··························41.8
5、支持治疗······························41.9统计学方法····························42.0结果··························4-52.1血液学缓解率··························42.2中位起效时间及中位无病生存时间········42.3随访情况·····························52.4不良反应·····························53.0讨论······························
6、··5-6locatedintheTomb,DongShenJiabang,deferthenextdayfocusedontheassassination.Linping,Zhejiang,1ofwhichliquorwinemasters(WuzhensaidinformationisCarpenter),whogotAfewbayonets,duetomissedfatal,whennightcame9宜顺论文网www.13Lw.com参考文献······························6-7近年来，随着我国经济的飞速发展，特别
7、是工业经济的快速发展，环境污染日益严重，致使造血系统疾病---白血病的情况不容乐观。白血病系造血系统的一种恶性疾病。在我国儿童及35岁以下人群发病和死亡中均居首位[1]，2004-2005年全国第三次死因回顾抽样调查显示，白血病居全国癌症死因的第六位[1]。其白血病预后一般较差，病死率较高，特别是目前国内外尚无明确预防和控制白血病发生的措施。急性白血病的治疗是一个系统工程，一般需要3-5年治疗时间目前，异基因造血干细胞移植及格列卫被认为是粒细胞白血病的最有效方法[2]。但受到种种条件的限制，诸如供体缺乏、风险大及费用高等，很多患者，尤其广大农村及低收
8、入患者无法接受上述治疗。干扰素虽有一定疗效，但存在发热、骨痛等不良反应。为寻找价廉有效的治疗手段，我们应用阿
