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1、中国临床康复第10巷第5期2006-02-10出版158ChineseJournalofClinicalRehabilitation,February102006Vol.10No.5·BASICRESEARCHEffectofN-acetylglucosamineonosteoblasticactivityandexpressionofbonemorphogeneticproteininfracturehealing"CuiYi-qun,ShenRuo-wuDepartmentofHumanAnatomy,MedicalColleg
2、eofQingdaoUniversity,CuiYQ,ShenRW.EffectofN-acetylglucosamineonosteoblasticactivityandex-Qingdao266021,ShandongProvince,Chinapressionofbonemorphogeneticproteininfracturehealing.ZhongguoGinchuangKangfu2006;10151:158-601ChinalIvvvvnv.zglckf.comlCuiYi-qun*,Master,Associat
3、eprofessor,DepartmentofHumanAnatomy,MedicalCollegeofQingdaoUniversity,Qingdao266021,ShandongProvince,Chinacuiyiqun@tom.comINTRODUCTIONReceived:2005-06-14Accepted:2005-10-20(04-25-12-8503/ZS)Astheonlypositiveionhigh-molecularpolymeravailableatpresent,chitinispreparedfro
4、mthepositivelychargedglu-AbstractcosamineextractedfromtheshellsoftheshellfishspecieswithBACKGROUND:Chitinanditsderivativespossessmanybiologicalac-solubilityinacidsolutionandabsorbability.Ithasstrongaffinitytivitiessuchasimmunemodulationandpromotingwoundhealingandtocell
5、swithsuchactivitiesinvivoasantibiosis,enhancingim-hemostasis.Asoneofthederivativesofchitin,theeffectofN-acetylglu-cosamineonfracturehealinghasnotyetbeenacknowledged.munity,retainingmoisture,adsorbingandeliminatingdepositedOBJECTIVE:Toobservethechangesinosteoblasticacti
6、vityandtheex-harmfulsubstances,henceitsnameofthesixthessentialele-pressionofbonemorphogeneticprotein(BMP)inresponsetotheinterven-mentoflifetogetherwithvegetativefiber.Chitinanditsderiva-tionwithN-acetylglucosamineduringthefracturehealing.tiveshasprovedtopossessingvario
7、usfunctionssuchasmodulat-DESIGN:Arandomizedcontrolledexperimentingimmunity,suppressingtumorgrowth,promotingwoundheal-SETTING:DepartmentofAnatomy,MedicalCollegeofQingdaoUniversity.MATERIALS:ThisexperimentwascarriedoutintheLaboratoryofing,aswellpromotinghemostasis,reduci
8、ngbloodpressureandNeuroanatomy,MedicalCollogeofQingdaoUniversityfromMarchtoAu-cholesterol0,2I,butitseffectonthefractu
