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1、ARTICLEINPRESSBON-08666;No.ofpages:8;4C:Bonexxx(2009)xxx–xxxContentslistsavailableatScienceDirectBonejournalhomepage:www.elsevier.com/locate/boneHydrolyzedcollagenimprovesbonemetabolismandbiomechanicalparametersinovariectomizedmice:Aninvitroandinvivostudya,b,d
2、cda,bFannyGuillerminet,HélèneBeaupied,VéroniqueFabien-Soulé,DanielTomé,cea,b,⁎Claude-LaurentBenhamou,ChristianRoux,AnneBlaisaINRA,UMR914NutritionPhysiologyandIngestiveBehavior,75005Paris,FrancebAgroParisTech,UMR914NutritionPhysiologyandIngestiveBehavior,75005P
3、aris,FrancecInsermU658,OrleansRegionalHospitalandUniversityofOrleans,Orleans45000,FrancedRousselotSAS,6rueJeanJaurès,92807Puteaux,FranceeUniversitéParisDescartes,DépartementdeRhumatologie,APHP,HôpitalCochin,Paris,FrancearticleinfoabstractArticlehistory:Collage
4、nhasanimportantstructuralfunctioninseveralorgansofthebody,especiallyinboneandcartilage.TheReceived8June2009aimofthisstudywastoinvestigatetheeffectofhydrolyzedcollagenonbonemetabolism,especiallyintheRevised26October2009perspectiveofosteoporosistreatmentandunder
5、standingofitsmechanismofaction.AninvivostudywascarriedAccepted28October2009outin12-week-oldfemaleC3H/HeNmice.Thesewereeitherovariectomized(OVX)orsham-operated(SHAM)Availableonlinexxxxandfedfor12weekswithadietcontaining10or25g/kgofhydrolyzedcollagen.Wemeasuredb
6、onemineraldensity(BMD)usingdual-energyX-rayabsorptiometry(DXA).C-terminaltelopeptideoftypeIcollagen(CTX),Editedby:D.Burrmarkerofboneresorption,andalkalinephosphatase(ALP),markerofboneformation,wereassayedafter4andKeywords:12weeks.Femurbiomechanicalpropertieswe
7、restudiedbya3-pointbendingtestandbonearchitecturebyOsteoblastmicrotomography.TheBMDforOVXmicefedthedietincluding25g/kgofhydrolyzedcollagenwassignificantlyOsteoclasthigherascomparedtoOVXmice.ThebloodCTXlevelsignificantlydecreasedwhenmicewerefedwitheitherofHydroly
8、zedcollagenthedietscontaininghydrolyzedcollagen.Finally,wehaveshownasignificantincreaseinbonestrengthBonemineraldensitycorrelatedtogeometricalchangesfortheOVXmicefedthe25g/kghydroly
