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1、GeneRegulationandMetabolismComputationalMolecularBiologySorinIstrail,PavelPevzner,andMichaelWaterman,editorsComputationalMethodsforModelingBiochemicalNetworksJamesM.BowerandHamidBolouri,editors,2000ComputationalMolecularBiology:AnAlgorithmicApproachPavelA.Pevzn
2、er,2000CurrentTopicsinComputationalMolecularBiologyTaoJiang,YingXu,andMichaelQ.Zhang,editors,2002GeneRegulationandMetabolism:PostgenomicComputationalApproachesJulioCollado-VidesandRalfHofesta¨dt,editors,2002MicroarraysforanIntegrativeGenomicsIsaacS.Kohane,Alvin
3、Kho,andAtulJ.Butte,2002GeneRegulationandMetabolismPostgenomicComputationalApproacheseditedbyJulioCollado-VidesandRalfHofesta¨dtABradfordBookTheMITPressCambridge,MassachusettsLondon,England(2002MassachusettsInstituteofTechnologyAllrightsreserved.Nopartofthisbook
4、maybereproducedinanyformbyanyelectronicormechanicalmeans(includingphotocopying,recording,orinformationstorageandre-trieval)withoutpermissioninwritingfromthepublisher.ThisbookwassetinPalatinoon3B2byAscoTypesetters,HongKongandwasprintedandboundintheUnitedStatesof
5、America.LibraryofCongressCataloging-in-PublicationDataGeneregulationandmetabolism:postgenomiccomputationalapproaches/editedbyJulioCollado-Vides&RalfHofesta¨dt.p.cm.—(Computationalmolecularbiology)Includesbibliographicalreferencesandindex.ISBN0-262-03297-X(hc.:a
6、lk.paper)1.Genetics—Mathematicalmodels.2.Molecularbiology—Mathematicalmodels.I.Collado-Vides,Julio.II.Hofesta¨dt,Ralf.III.Series.QH438.4.M3G462002572.800105118—dc212001056247ContentsPrefacevii1AretheEyesHomologous?1JeremyC.AhouseIInformationandKnowledgeRepresen
7、tation172AutomationofProteinSequenceCharacterizationandItsApplicationinWholeProteomeAnalysis19RolfApweiler,MargaretBiswas,WolfgangFleischmann,EvgeniaV.Kriventseva,andNicolaMulder3InformationFusionandMetabolicNetworkControl49AndreasFreier,RalfHofesta¨dt,Matthias
8、Lange,andUweScholzIIGeneRegulation:FromSequencetoNetworks854SpecificityofProtein-DNAInteractions87GaryD.Stormo5GenomicsofGeneRegulation:TheViewfromEscherichiacoli103JulioColl
