欢迎来到天天文库
浏览记录
ID:40706005
大小:2.61 MB
页数:72页
时间:2019-08-06
《20150104regulation of gene-pdf》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、李迺昶DrNaichangLiMSc.MD.PhD.DepartmentofBiochemistry&molecularbiology目录1.IntroductionandBiomedicalimportance2.RegulationofProkaryoticGeneExpression3.Specialfeaturesareinvolvedinregulationofeukaryoticgenetranscription4.Generegulationinprokaryotesandeukaryotesdiffersinimportantres
2、pects目录1.Introduction(1)Gene:is"alocatableregionofgenomicsequence,correspondingtoaunitofinheritance,whichisassociatedwithregulatoryregions,transcribedregions,andorotherfunctionalsequenceregions".(2)Geneexpression:TheprocessofproducingabiologicallyfunctionalmoleculeofeitherRNAo
3、rproteiniscalledgeneexpression.Gene:25000(3)RegulationofGeneexpression?目录Regulationofgeneexpressionalabelforthecellularprocessesthatcontroltherateandmannerofgeneexpression.Acomplexsetofinteractionsbetweengenes,RNAmolecules,proteins(transcriptionfactors)andothercomponentsofthee
4、xpressionsystemdeterminewhenandwherespecificgenesareactivatedandtheamountofproteinorRNAproductproduced.forexampletotriggerdevelopmentalpathways,respondtoenvironmentalstimuli,oradapttonewfoodsources.目录BiomedicalimportanceRegulatedexpressionofgenesisrequiredfordevelopment,differ
5、entiation,andadaptation维持细胞分化和个体发育适应环境、维持生长和增殖目录EffectsofPositiveandNegativeRegulationonGeneExpressionRateofGeneRepressorActivator目录BiologicSystemsExhibitThreeTypesOfTemporalResponsesToARegulatorySignaltypeAresponsetypeBresponsetypeCresponse目录typeAresponse:dependentuponthecont
6、inuedpresenceoftheinducingsignal.依赖诱导信号typeBresponse:transienteveninthecontinuedpresenceoftheregulatorysignal.typeCresponse:Thesignalactsasatrigger.目录Principlesofgeneregulation•Theexpressionofgenesisregulatedbyprocessesthataffecttheratesatwhichgeneproductsaresynthesizedanddegr
7、aded.Initiationoftranscriptionisacrucialregulationpointforbothprokaryoticandeukaryoticgeneexpression.呈现多层次和复杂性,转录起始是关键点●Transcriptioncontrolsoperateatthelevelofprotein-DNAandprotein-proteininteractions.目录1.SynthesisoftheprimaryRNAtranscript(transcription)2.Posttranscriptionalm
8、odificationofmRNA3.MessengerRNAdegradation4.Proteinsynthesis(
此文档下载收益归作者所有
点击更多查看相关文章~~