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1、GeneRegulationandMetabolismComputationalMolecularBiologySorinIstrail,PavelPevzner,andMichaelWaterman,editorsComputationalMethodsforModelingBiochemicalNetworksJamesM.BowerandHamidBolouri,editors,2000ComputationalMolecularBiology:AnAlgorithmicApproachPavelA.Pevzner,2000CurrentTo
2、picsinComputationalMolecularBiologyTaoJiang,YingXu,andMichaelQ.Zhang,editors,2002GeneRegulationandMetabolism:PostgenomicComputationalApproachesJulioCollado-VidesandRalfHofesta¨dt,editors,2002MicroarraysforanIntegrativeGenomicsIsaacS.Kohane,AlvinKho,andAtulJ.Butte,2002GeneRegul
3、ationandMetabolismPostgenomicComputationalApproacheseditedbyJulioCollado-VidesandRalfHofesta¨dtABradfordBookTheMITPressCambridge,MassachusettsLondon,England(2002MassachusettsInstituteofTechnologyAllrightsreserved.Nopartofthisbookmaybereproducedinanyformbyanyelectronicormechani
4、calmeans(includingphotocopying,recording,orinformationstorageandre-trieval)withoutpermissioninwritingfromthepublisher.ThisbookwassetinPalatinoon3B2byAscoTypesetters,HongKongandwasprintedandboundintheUnitedStatesofAmerica.LibraryofCongressCataloging-in-PublicationDataGeneregula
5、tionandmetabolism:postgenomiccomputationalapproaches/editedbyJulioCollado-Vides&RalfHofesta¨dt.p.cm.—(Computationalmolecularbiology)Includesbibliographicalreferencesandindex.ISBN0-262-03297-X(hc.:alk.paper)1.Genetics—Mathematicalmodels.2.Molecularbiology—Mathematicalmodels.I.C
6、ollado-Vides,Julio.II.Hofesta¨dt,Ralf.III.Series.QH438.4.M3G462002572.800105118—dc212001056247ContentsPrefacevii1AretheEyesHomologous?1JeremyC.AhouseIInformationandKnowledgeRepresentation172AutomationofProteinSequenceCharacterizationandItsApplicationinWholeProteomeAnalysis19Ro
7、lfApweiler,MargaretBiswas,WolfgangFleischmann,EvgeniaV.Kriventseva,andNicolaMulder3InformationFusionandMetabolicNetworkControl49AndreasFreier,RalfHofesta¨dt,MatthiasLange,andUweScholzIIGeneRegulation:FromSequencetoNetworks854SpecificityofProtein-DNAInteractions87GaryD.Stormo5Ge
8、nomicsofGeneRegulation:TheViewfromEscherichiacoli103JulioColl
