丹参对缺血再灌注损伤皮瓣成活率的影响

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1、中国组织工程研究与临床康复第15卷第5期2011–01–29出版JournalofClinicalRehabilitativeTissueEngineeringResearchJanuary29,2011Vol.15,No.5丹参对缺血再灌注损伤皮瓣成活率的影响*★何志，仇树林EffectsofsalviamiltiorrhizaonsurvivalrateofflapswithischemiareperfusioninjuryHeZhi,QiuShu-linAbstractBACKGROUND:Salviamiltiorrhiza(SM)isc

2、onsideredtobehelpfultopreventflapischemia-reperfusioninjury(IR),buttheDepartmentofBurnsspecificmechanismisnotclear.andPlasticSurgery,People’sHospitalofOBJECTIVE:ToobservetheprotectiveeffectsofSMinjectionontheflapIRinjuryinratsandtoexploreitsmechanism.HebeiProvince,METHODS:Tot

3、ally48Wistarratswererandomlydividedinto3groups,with16animalsineachgroup.NoperfusionwasShijiazhuangperformedinthecontrolgroup.Physiologicalsaline(2mL/kg)wasintraperitonealinjectedintoratsat3daysbeforeuntil5days050051,HebeiafteroperationintheIRgroup.ThesamevolumeofSMinjectionwa

4、sinjectedintoratsintheSM-IRgroup.ThecontentsofProvince,Chinamalonaldehyde,myeloperoxidase,intercellularadhesionmolecule1(ICAM-1)andnuclearfactor-κBoftheislandskinflapIRHeZhi★,Master,modelsweremeasured,andthesurvivalrateofflapwasobservedusingimageanalysis.DepartmentofBurnsRESU

5、LTSANDCONCLUSION:Theexpressionsofmalonaldehyde,myeloperoxidase,ICAM-1andnuclearfactor-κBintheIRandPlasticSurgery,group,SM-IRgroupafterreperfusion2,8,24hoursandthecontrolgroupafter10,16,32hoursshowed:IRgroup>SM-IRgroupPeople’sHospitalof>controlgroup(P<0.01).Thesurvivalrateoffl

6、apwas:IRgroup

7、sioninjury,thus,promoteflapsurvival.Province,Chinamodernhuatuo@163.HeZ,QiuSL.Effectsofsalviamiltiorrhizaonsurvivalrateofflapswithischemiareperfusioninjury.ZhongguoZuzhiGongchengcomYanjiuyuLinchuangKangfu.2011;15(5):855-860.[http://www.crter.cnhttp://en.zglckf.com]Corresponden

8、ceto:QiuShu-lin,摘要Professor,Master’ssupervisor,背景：丹参被认为有防治皮瓣缺血再灌注损伤的