丹参多酚酸盐对大鼠局灶脑缺血再灌注损伤的影响

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1、Theeffectofsa／vianolateOilthefocalcerebralischemia-rcpcrfusioninjuryinratsAbstracteffectofsalvianolateonthefocalcerebral●■●●●●lSCnemla—reDerIUSlonlnlUlVinratsAbstractPart1：Theeffectofsalvianolateonthefocalcerebralischemia-reperfusioninjuryinrats‘Objective：to

2、detecttheprotectiveeffectofSalvianolteonthefocalcerebralischemia-reperfusioninjuryinratsandtorevealthemechanism．Methods：48SDratsweredividedintofourgrouprandomly,normalcontrolgroup，ischemiacontrolgroup，salvianolate(10mg／kg)groupandsalvianolate(30mg／kg)group，e

3、achgroupcontein6rats．WeusedtheLongamethodtoestablishtheMCAOmodel．Thesalvianolteatdifferentdosewere蠲ectedintropedtoneallyatthedifferenttimepo缸accordingtothetestdesign．ThebraininfarctvolumebyTTCstainandbehaviorSCOI'eSbYLong’Smethodswerealsodeterminedinordertoe

4、valuatedtheprotectiveeffect．Alsowe墩assaykittodeterminetheactivitiesofSODandGSH·Ix,contentofMDAandNOineachgroup．Results：(1)：TheactivitiesofSODandGSH-Pxofbraintissueintheischemiacontrolgroup，salvianolate(10mg／kg)groupandsalvianolate(30mg／kg)group勰muchlowerthan

5、thoseinnormalcontrolgroup．Butthesalvianotescaninhibitthisdecrease．(2)：ThecontentofMDAofbraintissueintheischemiacontrolgroup，salvianolate(10mg／kg)groupandsalvianolate(30mg／kg)grouparemuchhigherthanthoseinnormalcontrolgroup．Thesalvianolate啪inhibitthisincrease．

6、(3)：ThecontentofNOofbraintissueintheischemiacontrolgroup，salvianolate(10mg／l(曲一groupandsalvianolate(30mg／kg)grouparemuchhigherthanthoseinnormalcontrolgroup．ThesalvianolateCaninhibitthisincrease．Conclusion：Thesalvianolateplaysneuropectiveeffectmaybethroughmod

7、ulatingtheimbalanceofoxidantandantioxidantinducingbythecerebralischemia-reperfusion．VTheeffectofsalvianolateonthefocalcerebralischemia-reperfusion询uryinratsAbstractPart2：TheeffectofsalvianolateontheexpressionofBDNFandGDNFproteinofthebraintissuefollowingfocal

8、cerebralischemia—reperfusioninratsObjective：toobservetheeffectofsalvianolateontheexpressionofBDNFandGDNFproteinofthebraintissuefollowingfocalcerebralischemia-reperfusioninrats，andtorevealthemech