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1、1、分别写出2010年以来，国际上与Ovariancancer、Breastcancer、Leukemia相关的文献有多少篇？写出3篇研究性论文标题和摘要，写出5篇综述性论文标题和摘要；数据库：科学引文索引数据库(SCI：ScienceCitationIndex)http://isiknowledge.com与Ovariancancer相关的文献有11,303篇与Breastcancer相关的文献有56,209篇与Leukemia相关的文献有32,912篇综述性论文标题和摘要1.Hemochromatosisandovariancancer摘要:Evaluationof:Gan
2、nonPO,MedelciS,LePageCetal.Impactofhemochromatosisgene(HFE)mutationsonepithelialovariancancerriskandprognosis.Int.J.Cancer128(10),2326-2334(2011).Thefrequencyoftwomutations(C282YandD62H)ofthehemochromatosisgenewereinvestigatedinwomenwithovariancancer.AsingleallelemutationoftheC282YbutnottheH
3、63Dgeneproductwasdetectedin8-9%ofwomenwithbenignovariantumors(n=124)andovariancancers(n=360)comparedwith2.5%forcontrols(n=80)representinga4.9-foldincreaseinrisk.Withhigh-gradeserousovariancancers(n=179),thesurvivalrateofwomenwithasinglealleleC282Ymutationwasreducedfrom39to19months.Theseresul
4、tsimplicatemutationsofthehemochromatosisgeneinthegenerationandseverityofovariancancers,whichmayhaveprognosticvalue.2.Differencesbetweenwomenwhopursuedgenetictestingforhereditarybreastandovariancancerandtheirat-riskrelativeswhodidnot.摘要:Purpose/Objectives:To(a)examinedifferencesinappraisalsof
5、hereditarybreastandovariancancer(HBOC),psychologicaldistress,familyenvironment,anddecisionalconflictbetweenwomenwhopursuedgenetictestingandtheirat-riskrelativeswhodidnot,and(b)examinecorrelationsamongappraisalsofHBOC,psychologicaldistress,familyenvironment,anddecisionalconflictregardinggenet
6、ictestinginthesetwocohortsofwomen.Design:Descriptive,cross-sectionalcohortstudy.Setting:TwoclinicsaffiliatedwithamajorresearchuniversityinthemidwesternUnitedStates.Sample:372womenaged18yearsandolder.200pursuedgenetictestingforBRCA1andBRCA2mutations(probands)and172oftheirfemalerelativeswhohad
7、agreaterthan10%priorprobabilityofbeingamutationcarrierbuthadnotpursuedtesting.Methods:Afterprovidinginformedconsent,probandsandrelativesweremailedself-administeredquestionnaires.MainResearchVariables:Perceivedrisk,knowledgeofHBOCriskfactorsandmodes
