化疗药物配制指南

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1、化疗药配备CommonAntineoplasticDrugPharmacyPreparationChartGenericName(INN)TradeNameConcentration/DiluentPrecautions/StockSolutionStabilityVehicleforInfusionPrecautions/Ready-to-UseSolutionStabilityAmifostineEthyol500mgin9.7mLof0.9%NaCl6hrs(RT)24hrs(refrigerated)n.r.Administerwithin25min

2、utesAsparaginaseAsparaginase10,000Uin4mLofWFIInthedark,6hrs)5%Dex/0.9%NaCl AzathioprineImurek50mgin5-15mLofWFI120hrs(RTorrefrigerated)0.9%NaClor0.18%NaCl+4%DexAdministerafterpreparationBleomycinBleomycin Numerousincompatibilities0.9%NaCl CarboplatinCarboplat50mgin5mLInthedark5%Dex/

3、0.9%NaClConc>0.5mg/mL8hrs(RT)24hrs(refrigerated)Carmustine(BCNU)CarmubrisDissolvein3mLofethanol,add27mLofWFI100mgin30mL5%Dex/0.9%NaCl0.9%NaCl8hrs(RT)24hrs(refrigerated)CisplatinPlatinex50mgin100mLInthedark,RT0.9%NaCl8hrs(RT)CladribineLeustatin10mgin10mL 0.9%NaClAdministerwithin<8hr

4、s(refrigerated)CyclophosphamideEndoxan1,000mgin50mLofWFI24hrs(refrigerated)5%Dex/0.9%NaCl CytarabineAlexan100mgin5mL 5%Dex /0.9%NaClDacarbazine(DTIC)Detimedac100mgin10mLofWFIInthedark;prepareimmediatelybeforeuse5%Dex/0.9%NaClAdministerwithin<30minDactinomycinLyovac-CosmogenDissolve

5、in1.1mLofWFI0.5mgin1mLInthedark5%Dex/0.9%NaCl DaunorubicinDaunoblastin100mgin10mLofWFIInthedark,24hrs(RT),48hrs(refrigerated)  DocetaxelTaxotere80mgin8mLPrepareimmediatelybeforeuse5%Dex/0.9%NaClConc<0.74mg/mL4hrs(RT)Doxorubicin(Adriamycin)Adriblastin50mgin25mLInthedark,refrigerated

6、N/A,bolusInjectwithin10-15minEpirubicinFarmorubicin50mgin25mLInthedark,refrigeratedN/A,bolusInjectwithin10-15minEstramustinePhosphateEstracyt300mgin8mLofWFIPrepareimmediatelybeforeuse5%DexNONaCl!12hrs(RT)24hrs(refrigerated)EtoposideVepesidJ100mgin5mL 5%Dex/0.9%24hrsat0.4EtoposidePh

7、osphateEtopophos100mgof[etoposide]in10mLofWFI,5%Dex,or0.9%NaClAdministerafterpreparation5%Dex/0.9%NaClConc>0.1mg/mLAdministerafterpreparationFilgrastim(G-CSF)Neupogen300µgin1mLRefrigerated5%Dex.NONaClConc>24hrs(refrigerated)2µg/mLFludarabineFludara50mgin2mLofWFI8hrs5%Dex/0.9%NaCl F

8、luorouracil(5-FU)Fluroblas