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1、喉部鼻型NK/T细胞淋巴瘤一例临床分析并文献复习PhundreimayumRaeesAhmed1，谢敏2【摘要】目的研究喉部鼻型NK/T细胞淋巴瘤的临床表现、病理特点及免疫表型，提高对本病的认识。方法对收治的1例喉部鼻型NK/T细胞淋巴瘤进行介绍，并对2001年至2012年国内发表的该病报道进行回顾性分析。结果纳入8篇报道共10例确诊为喉部鼻型NK/T细胞淋巴瘤患者。患者多中年起病，临床表现多样，最常见首发症状为声音嘶哑（80%）。病变最常累及的部位为声带（87.5%），出现表面增生或浸润性肿块（85.7%）、粘膜肿胀（57.1
2、%）。其镜下最常见表现为大片坏死组织，淋巴细胞增生活跃（55.6%）。免疫组化CD45RO、TIA-1、EBER1/2的阳性率均为100%，而CD56、粒酶B的阳性率为75%。结论喉部鼻型NK/T细胞淋巴瘤的临床表现多样，但其具有独特的病理、免疫学特点。【关键词】喉部；鼻型NK/T细胞淋巴瘤；临床分析ClinicalAnalysisof1CaseofLaryngealNasal-NK/T-CellLymphomawithLiteratureReviewPHUNDREIMAYUMRaeesAhmed1,XIEMin21Depart
3、mentofRespiration,JawaharlalNehruHospital,Imphal,Manipur,India2DepartmentofRespiration,WestChinaHospitalofSichuanUniversity,Chengdu610041,Sichuan,ChinaAbstractObjective:ToimprovetheunderstandingofLaryngealNasal-NK/T-CellLymphomabyanalyzingitsclinical,pathologicalandi
4、mmunohistochemicalcharacteristics.Methods:Fulldescriptionof1caseoflaryngealnasal-NK/T-cellLymphomawasgiven,anddomesticreportsofitbetweenyear-2001to2012wereretrospectivelyanalyzed.Results:8reportswith10caseswerecollected.Mostpatientswereaffectedintheirmiddleage(90%)wi
5、thonsetagevariedaround39.0(±10.6)yearsold,anddiedofperipheralrespiratoryfailure.Mostcommoninitialsymptomwashoarseness(80%).Patients’clinicalmanifestationsvaried,whichincludedhoarseness(80%),sorethroatorforeignbodysensation(70%),fever(50%),hemoptysis(40%)andsoon.Thedi
6、agnosisreliedonthebiopsyanditspathological,immunohistochemical,hybridizationinsitutests.Themostcommonlyinvolvedlesionwaslocatedinvocalcords(87.5%),whichpresentedwithsuperficialhyperplasiaorinvasivemass(85.7%),mucosalswelling(57.1%).Scatteredallotypedcellsburiedintheb
7、ackgroundofnecrotictissuewasmostcommonlyseenundermicroscope,withfoliated-locatedactivehyperplasiclymphocytes(55.6%).Inimmunohistochemistry,CD45RO,TIA-1,EBER1/2havethe100%positiverate,andCD56,GranzymeB75%,whileCD5,CD15,CD43,D57,CD68,CD79a100%innegativerate.Conclusions
8、:Theclinicalmanifestationsoflaryngealnasal-NK/T-celllymphomavaried,butithasitsuniquepathologicalandimmunohistochemicalcharacteristi
