原发性高血压病人血浆中hcy、adm和cgrp浓度测定的意义

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1、原发性高血压病人血浆中HCY、ADM和CGRP浓度测定的意义【摘要】目的通过测定原发性高血压病人血浆同型半胱氨酸(homocysteineHCY)、肾上腺髓质素(adrenomedullinADM)、降钙素基因相关肽(CGRP)活性物质的水平，探讨血管活性物质与原发性高血压的关系，为原发性高血压的预防和治疗提供理论依据。方法随机选取未经治疗的原发性高血压病人42例作为研究组，按高血压分级标准分为3个亚组,，对照组选择20例同期健康体检的正常人。采受试者空腹静脉血，用荧光法定量检测HCY，用放射免疫法检测ADM和CGRP。结果（1）研究组血浆HCY、ADM浓度明显高

2、于对照组，而CGRP水平明显下降，有显著统计学差异(P均<0.01)。(2)研究组三个亚组1级组、2级组和3级组HCY、ADM水平随着血压升高而升高，组间差别有统计学意义(P<0.01)。(3)研究组血浆HCY与ADM浓度呈正相关(r=0.941，P<0.01)，与CGRP呈负相关(r=-0.480，P<0.01)。结论研究组血浆HCY、ADM水平明显升高，且血压越高，浓度越高，而CGRP水平随着血压的升高却明显降低；研究组HCY、CGRP水平变化，提示它们参与了高血压的发生与发展；ADM继发性升高，可阻止高血压进一步发展，对机体具有保护作

3、用。【关键词】原发性高血压；同型半胱氨酸；肾上腺髓质素；降钙素基因相关肽9　　　Abstract：ObjectiveTodetectthelevelsofplasmahomocysteine(HCY),adrenomedullin(ADM),calcitoningenerelatedpeptide(CGRP)inessentialhypertension(EH)patients,investigatewhethertheyareinvolvedinthepathogenesisofEH,andprovidethetheoreticbasisforitspreve

4、ntion.MethodsAtotalof42EHpatientswithouttakingmedicationwererandomlyenrolledinstudygroupwhichwasdividedintothreesubgroups,andanother20healthyvolunteerswereenrolledincontrolgroup.ThelevelofplasmaHCYwasmeasuredbymeansoffluorometricmethodwhilethelevelsofADMandCGRPweredeterminedbyradioimm

5、unoassay.Results(1)ThelevelsofplasmaHCYandADMinthestudygroupwerehigherthanthoseofthecontrolgroup,whereasthelevelofplasmaCGRPwaslower(P<0.01).(2)ThelevelsofHCYandADMinclassI,classIIandclassIIIsubgroupsincreasedalongwiththeascensionofthebloodpressure,andtherewerestatisticaldifference

6、sbetweenanytwoofthesubgroups(P<0.01).(3)InthestudygroupplasmaHCYwaspositivelycorrelatedwithADM(r=0.941,P<0.01),butnegativelycorrelatedwithCGRP(r=-0.480,P<0.01).ConclusionInEHpatients,theconcentrationsofplasmaHCYandADMincreaseandarepositivelycorrelatedwiththelevelofbloodpressu

7、re;theconcentrationofplasmaCGRPdecreasesand9isnegativelycorrelatedwiththelevelofbloodpressure.ThechangesinplasmaHCYandCGRPlevelinEHpatientssuggestthattheyareinvolvedinthepathogenesisandthedevelopmentofhypertension.ThesecondaryadvanceofADMcaninhibitthegrowthofhypertensionandprovideapro

8、tecti