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1、原发性高血压病和2型糖尿病血瘀证与非血瘀证患者抵抗素、脂联素水平比较作者：陈贵海,武丽,臧知明,邓巍,黄金刚,运晨霞【摘要】目的探讨原发性高血压病和2型糖尿病患者抵抗素、脂联素与血瘀证的关系。方法以原发性高血压和糖尿病患者为对象,空腹取静脉血制备血浆、血清,酶免法检测血清脂联素、抵抗素,放免法检测血清瘦素、胰岛素和血浆内皮素、肿瘤坏死因子,酶法检测血清血糖、总胆固醇、三酰甘油、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇。使用SAS9.1forwindows分析各项指标与血瘀证的关系。结果糖尿病组血瘀证检出率0
2、.423,高血压病组为0.246,差异有统计学意义;血瘀证检出率随着病程延长而增高。与非血瘀证组比较,血瘀证组瘦素、内皮素、肿瘤坏死因子水平升高,脂联素、胰岛素水平降低,血清抵抗素差异无统计学意义。与原发性高血压病患者比较,2型糖尿病患者抵抗素、脂联素、瘦素、胰岛素水平均升高,而内皮素、肿瘤坏死因子差异无统计学意义。结论脂联素与血瘀证形成负相关;肥胖致瘀可能是由脂肪因子调节血管活性因子实现的;肥胖性血瘀可能与抵抗素水平无关。【关键词】原发性高血压;2型糖尿病;肥胖;血瘀证;抵抗素;脂联素11 Abstr
3、act：ObjectiveToinvestigatethecorrelationbetweenresistin,adiponectinandthebloodstasissyndromeindiabeticandprimaryhypertensionpatients.MethodTheprimaryhypertensionanddiabetespatientsweredrawnveinbloodtomakeplasmaandserum.Enzymelinkedimmunosorbentassay(ELISA
4、)methodwasusedincheckingserumadiponectinandresistin.Radioimmuoassaymethodwasappliedincheckingseruminsulin,leptin,ETandtumornecrosisfactor(TNF).Thefastingbloodsugar,totalcholesterol(TC),triamid-glycerin(TG),highdenselipoprotein-cholesterol(HDL)andlowdensel
5、ipoprotein-cholesterol(LDL)weredetectedbythechemi-enzymicmethod.TherelationbetweentheindexesandbloodstasissyndromewasanalyzedbySAS9.1forwindows.ResultsThedetectablerateofthebloodstasissyndromeinthediabeticpatientswas0.423,while0.246intheprimaryhypertensio
6、npatients.Thedifferencewassignificantinstatistics.Incidenceofbloodstasissyndromeincreasedwiththecourseofillness.Comparedwiththenon-bloodstasissyndromegroup,thecontentofleptin,ETandTNFinthebloodstasissyndromegroupsignificantlyraised,butthecontentofadiponec
7、tinandinsulindiminished.Thecontentofresistindidnothaveobviouslychange.Comparedwiththeprimaryhypertensionpatients,thelevelofleptin,adiponectin,11resistin,insulininthediabeticpatientsraised,buttherewasn’tsignificantdifferenceinthelevelofETandTNF.Conclusions
8、Thereisnegativecorrelationbetweenadiponectinandthebloodstasissyndrome.Thelinkbetweenobesityandthebloodstasissyndromemaybethroughfatfactorregulatingvasoactivefactor.Thebloodstasissyndromecausedbyobesitymaybehavenothi
