hbeag阴性慢性乙型肝炎中医证型分布及与hbvdna、肝纤四项关系的研究

《hbeag阴性慢性乙型肝炎中医证型分布及与hbvdna、肝纤四项关系的研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、HBeAg阴性慢性乙型肝炎中医证型分布及与HBVDNA、肝纤四项关系的研究作者：陈培琼,张金珍,田广俊,池晓玲【摘要】目的探讨HBeAg阴性慢性乙型肝炎中医证型分布规律及各证型与实验室指标的关系。方法采用临床流行病学回顾性研究方法,从2008年1月－2009年5月就诊于广东省中医院门诊及住院患者中选取合格研究对象329例,观察其肝功能、HBVDNA、肝纤四项等实验室指标。结果各证型的分布为：肝郁脾虚＞湿热中阻＞肝肾阴虚＞瘀血阻络＞脾肾阳虚。湿热中阻证的血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)水平明显高于其他证型(P＜0.05)。当HBVD

2、NA＜104copies/mL时,湿热中阻证的频数明显高于其他证型(P＜0.05)；而当104≤HBVDNA＜107copies/mL时则相反。湿热中阻证三型前胶原(PCⅢ)的异常率明显高于肝郁脾虚、肝肾阴虚证,肝肾阴虚证层粘连蛋白(LN)、透明质酸(HA)的异常率及瘀血阻络证HA的异常率均明显高于肝郁脾虚、湿热中阻证(P＜0.05)；而肝郁脾虚证Ⅳ型胶原(CⅣ)的异常率与湿热中阻证差异没有统计学意义(P＞0.05)。结论HBeAg阴性慢性乙型肝炎的中医证型分布具有一定的规律；各证型与转氨酶、HBVDNA、肝纤四项等实验室指标之间有一定的内在关系。【关键词】乙

3、肝e抗原阴性；慢性乙型肝炎；中医证型；转氨酶；HBVDNA；肝纤维化指标11Abstract：ObjectiveToresearchthedistributioncharacteristicofTCMsyndrometypesandtheirrelationshipwithlaboratorialtestsinpatientswithHBeantigen-negativechronichepatitisB.MethodClinicalepidemiologicalretrospectiveinvestigationwasadopted.329casesofGu

4、angdongProvincialHospitalofTCMfromeJanuary2008toMay2009wereinvolved,andtheirhepaticfunction,HBVDNAandhepaticfibrosismarkersweretested.ResultTheproportionsofTCMtypeofsyndromesin329patientsincludedthesurveywere：liverdepressionandinsufficiencyofthespleen(typeA)＞dampness-heataccumulatio

5、n(typeB)＞liver-kidneyyindeficiency(typeC)＞obstructionofcolletaralsbybloodstasis(typeD)＞insufficiencyofboththespleenandthekidney(typeE).TheserumlevelsofALTandASTintypeBweresignificantlymorehigherthantheothersyndromes(P＜0.05).WhentherangeofreplicationofHBVDNAbelow104copies/mL,thefrequ

6、encyoftypeBwasremarkablylessthanthatoftheothertypes,whichwasoppositewhentherangeofreplicationofHBVDNAbetween104copies/mLand107copies/mL(P＜0.05).ThepercentageoftypeBwithabnormalPCⅢwashigherthantypeAandtypeC,whilethepercentageoftypeCwithabnormalLNor11HAandthepercentageoftypeDwithabnor

7、malHAwerehigherthantypeAandtypeB(P＜0.05).TherewasnodifferencebetweentherateofabnormalCⅣintypeAandthatintypeB(P＞0.05).ConclusionThedistributionofTCMtypesofsyndromeofthepatientswithHBeAg-negativechronichepatitisBhasitscharacteristic.TherearesomerelationshipsbetweenTCMtypesofsyndromean

8、dthelevelsoftransam