利咽解毒方防治鼻咽癌急性放射性口腔黏膜反应临床观察

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1、利咽解毒方防治鼻咽癌急性放射性口腔黏膜反应临床观察作者：张红,王艳云,何欣,曾柏荣,张志芳【摘要】目的观察利咽解毒方防治鼻咽癌急性放射性口腔黏膜反应的临床疗效及其对鼻咽癌放疗疗效的影响。方法96例患者随机分为治疗组、对照组,各48例。2组均行根治性放疗。治疗组予中药利咽解毒方含服,对照组予西药含漱,2组疗程均从放疗开始至放疗结束。结果治疗组及对照组黏膜反应发生的时间分别为(21±4.2)、(16±3.6)d,放射剂量分别为(40.252±11.758)、(29.625±11.632)Gy,差异有显著性(P<0.05)。2组放射性口腔黏膜反应发生率差异有显

2、著性,治疗组损伤程度明显低于对照组(P<0.01)。2组口腔黏膜反应愈合有效率比较,差异有显著性(P<0.01)。治疗组及对照组总放疗时间分别为(48.78±2.03)、(52.43±3.18)d,差异有显著性(P<0.01)。放疗结束时,治疗组及对照组鼻咽部病灶残留率分别为10.42%、14.58%,颈部淋巴结转移灶残留率分别为34.29%、38.24%,差异无显著性。结论利咽解毒方能延迟鼻咽癌放疗患者黏膜反应发生的时间,提高其发生的剂量,降低反应级别,促进口腔黏膜反应愈合,对放疗效果无明显影响。【关键词】利咽解毒方；放射性口腔黏膜反应；鼻

3、咽癌11Abstract：ObjectiveToevaluatetheclinicaleffectofLiyanjiedudecoctionfortheprophylaxisandtreatmentofacuteradiotherapy-inducedoralmucositisofnasopharyngealcarcinoma(NPC)andtheinfluencetotheeffectoftheradiotherapytoNPC.MethodsAtotalof96patientswithNPCwererandomlydividedintotreatmentg

4、roupandcontrolgroup,48casesforeachgroup.Thetwogroupsweregivenradicalradiotherapy.ThetreatmentgroupwasgivenLiyanjiedudecoctionforbuccal.Thecontrolgroupweregivenwesternmedicineformouthwash.Thecourseoftwogroupswasallfromthebeginningofradiotherapytotheendofit.ResultsTheoccurringtimeofra

5、diotherapy-inducedmucositisintreatmentgroupandcontrolgroupwere(21±4.2)dand(16±3.6)d,andradiotherapeuticdosewere(40.252±11.758)Gyand(29.625±11.632)Gy,withsignificantdifferencebetweenthetowgroups(P<0.05).Theoccurrencerateofradio-inducedmucositishadsignificantdifferencebetweenthetwo

6、groups.Theinjuryofmucosaintreatmentgroupwaslessthancontrolgroup(P<0.01).Theeffectiverateoforalmucosahealingofthetreatmentgroupwasmuchbetterthancontrolgroup(P<0.01).Thetotalradiotherapeutictimewas(48.78±2.03)dintreatmentgroupand(52.43±3.18)dincontrolgroup(P<0.01).The11residu

7、alrateofpharynxnasalisafterradiotherapyintreatmentgroupandcontrolgroupwas10.42%and14.58%,andtheresidualrateoflymphnodeincervicalpartwas34.29%and38.24%.Therewasnosignificantdifferencebetweenthetwogroups.ConclusionLiyanjiedudecoctioncandelaythetimeandincreasethedoseofoccurringradiothe

8、rapy-inducedmucosit