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1、CD44v6、VEGF、CEA水平检测对良恶性胸腔积液鉴别的意义【摘要】目的探讨CD44v6、VEGF、CEA单项和联合检测对鉴别良恶性胸腔积液的价值。方法选取70名胸腔积液患者，其中良性疾病组患者35例，恶性疾病组患者35例。采用ELISA法检测胸腔积液CD44v6、VEGF、CEA水平。结果在恶性疾病组中，CD44v6、VEGF、CEA的平均检测值分别为（45.50±24.94）ng/ml、（458.66±194.26）pg/ml和（29.92±20.57）ng/ml，在良性疾病组中CD44v6、VEGF、CEA平均检测值分别为（13.64±10.75）ng/m
2、l、（137.88±73.72）pg/ml、（10.56±9.33）ng/ml。在单项检测中CD44v6、VEGF、CEA的敏感度分别为85.7％、91.4％、80.0％，特异度分别为80.0％、85.7％、71.4％；在联合检测中，VEGF+CD44v6组的敏感度为81.4％，特异度为90.0％；CD44v6＋CEA组敏感度为68.6％，特异度为91.4％；VEGF+CEA组的敏感度为72.9％，特异度为94.3％；VEGF+CD44v6＋CEA组敏感度为62.9％，特异度为96.2％。结论恶性疾病组胸腔积液CD44v6、VEGF、CEA水平分别明显高于良性疾病组
3、，差异有显著性。单项检测中，VEGF和CD44v6有较高的敏感度和特异度，而在联合检测中，以VEGF+CD44v6和VEGF+CEA的敏感度和特异度相对较高。刘志波（1977～），男，汉族，辽宁籍，青海大学医学院2005级研究生【关键词】胸腔积液CD44v6VEGFCEA联合检测鉴别诊断9AbstractObjectiveToobservethediagnosticvalueofCD44v6,VEGFandCEA indeterminationofbenignormalignantpleuraleffusion.MethodsAmong70patientswithp
4、leuraleffusion,35patientssufferedfrombenigndiseaseand35patientssufferedfrommalignantdisease.TheexpressionsofCD44v6,VEGFandCEAinpleuraleffusionweredetectedwithELISAtechnique.ResultsInthegroupofmalignantdiseases,theaveragevalueofCD44v6,VEGFandCEAwere45.50±24.94ng/ml,458.66±194.26pg/mland
5、(29.92±20.57)ng/ml,respectively.Inthegroupofbenigndisease,theaveragevalueofCD44v6,VEGFandCEAwere13.64±10.75ng/ml,137.88±73.72pg/mland10.56±9.33ng/ml,respectively.Insingledetermination,thesensitivityofCD44v6,VEGF,CEAwere85.7%,91.4%and80%,respectively.Thespecificitywere80%,85.7%and71.4%,
6、respectively;Incombineddetermination,thesensitivityofVEGF+CD44v6was81.4%,andthespecificitywas90.0%;ThesensitivityofCEA+VEGFwas72.9%andthespecificitywas94.3%;ThesensitivityofCEA+CD44v6was68.6%,thespecificitywas91.4%;ThesensitivityofVEGF+CD44v6+CEAwas62.9%,thespecificitywas96.2%.Conclusi
7、onThevalueofCD44v6,VEGFandCEAinmalignantdiseasegroupishigherthanthatinbenigndiseasegroup.Thereshowedsignificantdifference.Insingle9detection,VEGFandCD44v6havehighersensitivityandspecificity.Incombineddetection,thegroupsofVEGF+CD44v6andVEGF+CEAhavehighersensitivityandspecificity.Keywo
