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ID:14364123
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页数:9页
时间:2018-07-28
《transfer rna synthetase proofreading of amino acids》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、tRNASynthetaseSecondaryarticleProofreadingofAminoAcidsArticleContents.IntroductionHieronimJakubowski,UMDNJ-NewJerseyMedicalSchool,Newark,NewJersey,USA.HowAccurateareAminoacyl-tRNASynthetases?.FidelityoftRNAAminoacylationDependsonEditingInmanycases,theintrinsicbindingenergiesofaminoaci
2、dstoaminoacyl-tRNAsynthetases.EditingPathways:tRNA-independentandtRNA-dependentEditingareinadequatetogivetherequiredaccuracyoftranslation.Thishasnecessitatedthe.ChemistryofEditingevolutionofaseconddeterminantofspecificity,proofreadingoreditingmechanismsthat.MolecularBasisofEditinginvo
3、lvetheexpenditureofenergytoremoveerrorsinaminoacidselection..EditingOccursinvivo.SummaryIntroductionTheaccurateprocessingofgeneticinformationisfunda-mentaltotheevolutionandmaintenanceofstableformsofTable1ExamplesofeditingandtRNAmisacylationbyclasslife.Alllivingcellsmustconductproteins
4、ynthesiswithaIAARSshighdegreeofaccuracymaintainedinthetransmissionandRelativeflowofinformationfromgenetofinishedproteinproduct.RelativerateofOnecrucial‘qualitycontrol’pointinmaintainingahighAminoacyl-tRNArateofcharginglevelofaccuracyistheselectivitybywhichaminoacyl-24synthetaseandaminoa
5、cidediting10tRNAsynthetases(AARSs)furnishcorrectlyactivatedaminoacids,attachedtotRNAspecies,asthebuildingMethionyl-tRNAsynthetase4blocksforgrowingproteinchains.Methionine110TheAARSscarryouttwoimportantfunctionsinHomocysteine6050.01translation:informationtransferandchemicalactivation.
6、Norleucine57TheinformationtransferfunctioninvolvesmatchingEthionine713aminoacidswithcognatetRNAs.Eachofthe20AARSsIsoleucyl-tRNAsynthetaseselectsonecognateaminoacidfromover20bioticamino4Isoleucine110acidsandacognatetRNAfromthe20tRNAfamilies,Homocysteine7650.01accordingtotherulesofthege
7、neticcode.ThechemicalCysteine100activationfunctioninvolvesaminoacylationoftRNAinaLeucine6two-stepreactiondrivenbythehydrolysisofATP.IntheNorleucine12firststep(reaction[1]),acarboxylgroupofanaminoacidValine430.03(AA)isactivatedbyATP,forminganAARS-bounda-Aminobutyrate24aminoacyladenylate
8、.Thre
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