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1、ArachidonicAcidSecondaryarticleNicolasGBazan,LouisianaStateUniversityMedicalCenter,NewOrleans,Louisiana,USAArticleContents.IntroductionBioactivelipidshavesignificantneurobiologicalactionssuchasinthefunctionofion.LipidMetabolismintheNeuronalPlasmaMembranechannels,receptors,neurotransmitterrelease,sy
2、napticplasticityandprogrammesof.MetabolicFatesofArachidonicAcid:Prostaglandins,neuronalgeneexpression.Asaresult,thereisrapidincreaseinthesizeofthebrain’sfreeLeucotrienesandOtherEicosanoidsfattyacidpool,particularlyofarachidonicacid.Arachidonicacidisconvertedintoavariety.ArachidonicAcidinNeuronalCel
3、lDamageofbiologicallyactivederivativesthroughcyclooxygenationandlipoxygenation..ArachidonicAcidinSynapticActivity.SummaryIntroductionArachidonicacid(AA)belongstotheessentialfattyacidtheless,FFAsbythemselveshaveintrinsicpropertiesthatfamilythatoriginatesfromlinoleicacid.Linoleicacidismaketheiraccumu
4、lationundesirable(BallouandCheung,producedmainlyinplants,asanimportantcomponentof1985).vegetableoils.Becauselinoleicacidcontains18carbonsinPhospholipidsfromsynapticmembranesareanim-chainlengthandthreedoublebonds,theclosesttothe–portanttargetinseizures,headinjury,neurodegenerativeCH3terminalbeingsep
5、aratedbythreecarbons,itisdiseasesandcerebralischaemicdamage.Synapticmem-depictedas18:3n-6(oro-6).AAis,infact,20:4,n-6.branesaretermed‘excitablemembranes’becausetheyareTheelongatinganddesaturatingenzymesoflinoleicacidcapableofmaintainingandrapidlymodulating,inarelocatedmainlyintheliver,andAAisfoundi
6、nresponsetostimulus,substantialtransmembraneelectronlipoproteinsasarouteofdistributiontovarioustissuesandgradientsrequiringthepresenceofionpumpsandinessentiallyallcellmembranes.AAisesterifiedmainlyinchannels,neurotransmitterreceptors,andotherassociatedtheC2oftheglycerolbackboneand,assuch,playsamembr
7、aneproteins.Excitablemembraneshaveaphos-significantfunctionasamembranecomponentcontribut-pholipidcompositionthatdiffersfromotherneuralandingtounsaturateddomainsthatinfluencesthefunctionofnonneuralmembranes,apr
