Transcriptome Architecture of Adult Mouse Brain Revealed by Sparse Coding of Genome-Wide In Situ Hybridization Images.[2017][Neuroinformatics][10.1

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1、NeuroinformDOI10.1007/s12021-017-9333-1ORIGINALARTICLETranscriptomeArchitectureofAdultMouseBrainRevealedbySparseCodingofGenome-WideInSituHybridizationImages11111,24YujieLi&HanboChen&XiJiang&XiangLi&JingleiLv&MengLi&341HanchuanPeng&JoeZ.Tsien&TianmingLiu#SpringerScience+BusinessMediaNewYork2017Ab

2、stractHighlydifferentiatedbrainstructureswithdistinct-interpretationandexplorationsofthetranscriptomearchi-lydifferentphenotypesarecloselycorrelatedwiththeuniquetectureofamousebrain.combinationofgeneexpressionpatterns.Usingagenome-wideinsituhybridizationimagedatasetreleasedbyAllenKeywordsSparsec

3、oding.Data-drivengeneclustering.MouseBrainAtlas,wepresentadata-drivenmethodofdic-Transcriptome.Mousebrainanatomytionarylearningandsparsecoding.Ourresultsshowthatsparsecodingcanelucidatepatternsoftranscriptomeorgani-zationofmousebrain.AcollectionofcomponentsobtainedIntroductionfromsparsecodingdis

4、playrobustregion-specificmolecularsignaturescorrespondingtothecanonicalneuroanatomicalHighlydifferentiatedbrainstructureswithdistinctlydifferentsubdivisionsincludingfibertractsandventricularsystems.phenotypesarecloselycorrelatedwiththeuniquecombina-Othercomponentsrevealedfineranatomicaldelineati

5、onoftionofgeneexpressionpatterns(Jiangetal.2001;Modyetal.domainspreviouslyconsideredhomogeneous.Wealso2001).Manystudieshavereportedthattranscriptomescanbuildanopen-accessinformaticsportalthatcontainstheserveasimportant,informativemodalitiestoclassifycelldetailofeachcomponentalongwithitsontologya

6、ndtypesandrevealdeeperorganizationofbrainstructuresexpressedgenes.Thisportalallowsintuitivevisualization,(Heintz2004;Nelsonetal.2006;Windenetal.2009;Hawrylyczetal.2010).Anumberofmolecularmarkers,suchascalcium-bindingproteinsandgrowthfactors,werefoundtoYujieLiandHanboChenareCo-firstAuthors.showdi

7、stinctpatternsthatcanbeutilizedtodistinguishbe-HanchuanPeng,JoeZ.TsienandTianmingLiuareJointCorrespondingtweenfieldCA1andfieldCA3inadultmouseandratbrainsAuthors.(Woodhamsetal.1993).Toleetal.(Toleetal.1997)furtherElectronicsu