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1、Vol454
2、14August2008
3、doi:10.1038/nature07150LETTERSInternalbrainstateregulatesmembranepotentialsynchronyinbarrelcortexofbehavingmice11JamesF.A.Poulet&CarlC.H.PetersenInternalbrainstatesformkeydeterminantsforsensorypercep-brainstatecouldresultfromsensoryfeedbackgeneratedduring1,
4、2tion,sensorimotorcoordinationandlearning.Aprominentwhiskermovements,or,alternatively,itcouldbecentrallygenerated20,21reflectionofdifferentbrainstatesinthemammaliancentralnerv-withinthecentralnervoussystem.Todistinguishbetweentheseoussystemisthepresenceofdistinctpatternsofcort
5、icalsyn-twosources,wemadebilateralsectionsoftheIONs(Fig.1a,d).chrony,asrevealedbyextracellularrecordingsoftheWhiskingwasnotimpairedbycuttingtheIONs,becausethefacialelectroencephalogram,localfieldpotentialandactionpotentials.nerves,containingthemotorneuronaxons,wereleftintact.D
6、uringSuchtemporalcorrelationsofcorticalactivityarethoughttobewhisking,micewithintact(n510)andcut(n510)sensorynerves3–11fundamentalmechanismsofneuronalcomputation.However,showedastrongandsignificantdecreaseinthepoweroflowfre-itisunknownhowcorticalsynchronyisreflectedintheintrac
7、el-quency(1–5Hz)membranepotentialoscillations(Fig.1e)andinthelularmembranepotential(Vm)dynamicsofbehavinganimals.membranepotentialvariance(Fig.1f).Inbothgroupsofmice,layerHereweshow,usingdualwhole-cellrecordingsfromlayer2/32/3corticalneuronsdepolarizedslightlybutsignificantlyd
8、uringprimarysomatosensorybarrelcortexinbehavingmice,thatthewhisking(Fig.1g)withoutoverallchangesinfiringrates(Fig.1h).Vmofnearbyneuronsishighlycorrelatedduringquietwakeful-Noneoftheseparameterswassignificantlydifferentwhencomparingness.However,whenthemouseiswhisking,aninternal
9、lygener-preparationsinwhichthenervewasintacttothoseinwhichthenerveatedstatechangereducestheVmcorrelation,resultinginawascut(Fig.1e–h).Therefore,themostprominentchangesinbraindesynchronizedlocalfieldpotentialandelectroencephalogram.statecomparingquietwakefulnesstowhiskingperiod
10、sdonotActionpotentialactivitywassparseduringbothquietwakefuln
