mrsa感染的抗菌治疗

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1、MRSA感染的抗菌治疗6/14/20211McDonaldLC.ClinInfectDis.2006;42:S65-S71.NosocomialinfectionCommunity-acquiredinfectionPenicillinase-producingSaureus02550751001940196019802000YearResistantisolates(%)Methicillin-resistantSaureus02550751001940196019802000YearResistantiso

2、lates(%)ProgressionofresistantStaphylococcusaureusAsimilartrendintheincreaseinnosocomialinfectionscausedbyantimicrobial-resistantSaureusisolatescanbeobservedincommunity-acquiredinfections6/14/20212EmergenceofresistantpathogensIncreaseinnosocomialSaureusbac

3、teremiapredominantlyduetotheincreaseinMRSAintheUKWyllieD,etal.BMJ.2006;333:281-284.CohortstudyinOxfordshire,UK;MSSA=methicillin-sensitiveStaphylococcusaureusaPer100,000admissions;bP<.01;cP>.2.Year4005003002001501005019971999200020012002200320041998CasesofSau

4、reusBacteremia*Year4005003001501005019971999200020012002200320041998CasesofSaureusBacteremiaaAllNosocomialSaureusBacteremiabYear4005003002001501005019971999200020012002200320041998CasesofSaureusBacteremia*Year4005003002001501005019971999200020012002200320041

5、998CasesofSaureusBacteremiaaMSSAMRSAcb6/14/2021346/14/20214HA-MRSAStrainsHighlocalprevalenceHistoryofMRSAinfectionorcolonizationClosecontactwithinfectedindividualExtendedhospitalizationResidentofnursinghomeorlong-term-carefacilityInvasivedevicesDialysisCa

6、theterizationEnteralfeedingRecentantibioticuseRiskfactorsforinfectionwithMRSACA-MRSAStrainsHighlocalprevalenceHistoryofMRSAinfectionorcolonizationClosecontactwithinfectedindividualCrowdedand/orunsanitaryconditionsPrisonMilitarycampDepressedimmunesystemPar

7、ticipationincontactsportsSharingathleticequipment/towelsIntravenousdrugabuse1.MRSAInfection.MayoClinic.com2007.Availabeat:http://www.mayoclinic.com/health/mrsa/DS00735/DSECTION=4.2.GraffunderEM,VeneziaRA.JAntimicrobChemother.2002;49:999-1005.3.SafdarN,MakiD

8、G.AnnInternMed.2002;136:834-844.4.MoranGJ,etal.NEnglJMed.2006;355:666-74.6/14/202156/14/20216MRSA感染的危害MRSA感染可能增加死亡风险1增加患病率2,3延长住院时间2,3增加住院费用1,2,41.RubinRJ,etal.EmergInfectDis.1999;5:9-17.2.Carbo