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1、汉防己甲素配合放疗治疗局部晚期及复发直肠癌临床探究[摘要]目的探讨汉防己甲素(Tetrandrine,Tet)对局部晚期和复发直肠癌放疗增敏作用及其不良反应。方法回顾性分析2000年至2005年收治的局部晚期和复发直肠癌33例患者的临床资料，其中15例给予单纯放疗(放疗组),18例放疗的同时给予Tet(Tet组)。放疗采用15MVX线常规分割照射，病灶总量达60-66Gy/30~33F/6~7周。Tet组在照射第1天开始服用Tet，每次40mg，3次•d-1，直至放疗结束。结果两组患者局部症状缓解率均为100%,症状缓解开始的中位时间Tet组较放疗组短，但
2、差异无统计学意义(P>0.05)。Tet组和放疗组便血和疼痛症状缓解持续的中位时间分别为15个月和8个月，具有统计学差异（P0.05)。结论Tet配合放疗，能有效延长局部晚期和复发直肠癌局部症状缓解持续时间，生存率有提高趋势，可能是一种理想的放射增敏剂。�[关键词]汉防己甲素；放射治疗；直肠癌�[中图分类号]R735.37；R730.55[文献标识码]A[文章编号]1671-7562(2008)02-0097-04��RadiotherapywithTetrandrineforlocallyadvanced�
10andrecurrentrectalcancer��C
3、AOYuan-dong�1,SUNXin-chen�1,CHENGHong-yan�1,YUDa-hai�2,�GEXiao-lin�1,LIYi-kun�1,XUEYou-hua�1,LINQian�1,MAChun-yang�1(1.DepartmentofOncology,ZhongdaHospital，SoutheastUniversity,Nanjing210009,China;2.Departmentof�Radiotherapy,XuzhouHospitalAffiliatedtoMedicalCollegeofSoutheastUniversity,X
4、uzhou221009,China)��Abstract:ObjectiveTostudytheeffectofradiotherapycombinedwithTetrandrine(Tet)inthetreatmentoflocallyadvancedandrecurrentrectalcancer.MethodsThedataof33casesoflocallyadvancedandrecurrentrectalcancerfrom2000to2005wereanalysedretrospectively,ofwhich15patientsreceivedradi
5、otherapy(radiotherapygroup),18casesreceivedradiotherapycombinedwithTet(Tetgroup).Allpatientsweretreatedwithconventionalradiotherapyby15MVXraytoatotaldoseof60-66Gyin6-7weeksfortherespectabledisease.DuringradiotherapyoftheTetgroup,all10thepatientstookTet40mgeverytimeandthreetimesperday.Re
6、sultsLocalsymptomremissionratewas100%forthetwogroups.SymptomsremissionbeginningtimeoftheTetgroupwasshorterthantheradiotherapygroup，buthadnostatisticaldifference(P>0.05).HematocheziaandpainreliefsustainedmediantimeoftheTetgroupandtheradiotherapygroupwere15monthsand8months,andtherewasasig
7、nificantdifferencebetweenthetwogroups(P0.05).1,2,3-yearsurvivalratesoftheTetgroupandtheradiotherapygroupwere77.8%,44.4%,27.8%and64.3%,33.3%,20.0%,therewasnosignificantdifference(P>0.05).ConclusionTetwithradiotherapycaneffectivelyextendlocallysymptomremissiontimeforadvancedandre
