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1、基质金属蛋白酶-9及胰岛素抵抗与2型糖尿病颈动脉粥样硬化的相关性研究2007年第儿卷第4期实用临床医药杂志Jotwna1ofClinica1MedicineinPractice?53?基质金属蛋白酶一9及胰岛素抵抗与2型糖尿病颈动脉粥样硬化的相关性研究王艳,张真稳,朱妍,陈晖,刘彦,罗娜,王晓玲,陈勇.,孙晓芳,程英英(江苏省苏北人民医院,1.内分泌科;2.检验科;3.超声心动图室,江苏扬州,225001)摘要:目的研究2型糖尿病患者基质金属蛋白酶一9(MMP一9)及胰岛素抵抗与颈动脉粥样硬化的关系.方法采用ELISA
2、法分别检测正常人25例(对照组),按体重指数(BMI)分成糖尿病非肥胖组26例和糖尿病肥胖组34例患者的血清MMP-9水平和胰岛素抵抗指数(}I()MA_IR)等生化指标,应用彩色多普勒超声测量颈动脉内膜中层厚度(IMT)进行相关分析.结果糖尿病2组的HbAlc,FPG,FINS,HOMAIR,MMP-9,IMT的指标较对照组明显增高(P<0.05或0.O1),糖尿病肥胖组的FINS,HOMAIR,MMP-9的水平均高于非肥胖组(P<0.05或0.01),而HbA1c,FPG,IMT相比较没有显着性差异(P
3、>0.05).相关分析表明糖尿病2组血清MMP-9和HOMA-IR指标与IMT呈正相关.结论2型糖尿病患者颈动脉粥样硬化病变严重程度与血清MMP-9和HOMA-IR增高有密切的关系.关键词:基质金属蛋白酶一9;2型糖尿病;胰岛素抵抗;颈动脉内膜中层厚度中图分类号:R587.1文献标识码:A文章编号:1672—2353(2007)04-0053-03RelationshipofMatrixMetalloproteinase一9andInsulinResistancewithIntimal—mediaThicknes
4、sofCarotidArteryinType2DiabeticPatientsWANGYan,ZHANGZhen—wen,ZHUYan,etal(DepartmentofEndocrinology,SubeiPeopleHospital,Yangzhou,Jiangsu225001)ABSTRACT:0biectiveToinvestigatetherelationshipofmatrixmetalloproteinase一9(MMP一9)andinsulinresistance(HOMA-IR)withintimal
5、—mediathickness(IMT)ofcarotidarteryintype2diabeticpatients.MethodsSerumlevelsofMMP-9weredeterminedbyenzymelinkedimmu—neosorbentassay(ELISA)in34obesitiesoftype2diabetesmellitusand26non-obesitiesoftype2di—abetesmellitus.Theirintimal-mediathickness(IMT)ofcarotidart
6、eryandHOMA—IRwerealsomeasuredandanalyzed.25individualswithoutdiabeticsweretakenasthecontrolgroup.ResultsTheserumlevelsofHbAlc,FPG,FINS,MMP一9andHOⅣLA—IR,IMTinthetwoobservedgroupswithdiabeticsweremuchhigherthanthatinthecontrolgroup(P<0.05or0.01).ThelevelsofFINS
7、,HOMAIR,MMP一9intheobservedgroupwithobesitiesweresignificantlyhigherthanthatintheobservedgroupwithnon—obesities(P<0.05or0.01).However,therewasnotmuchdifferencebetweenthelevelsofHbAlc,FPG,(P>0.05).LinearregressionanalysisshowedthatserumlevelsofMMP一9,HOMA—IRw
8、erepositivelycorrelatedwithIMT.ConclusionTheseverityofcarotidatherosclerosisintype2diabeticsmellitusiscloselyassociatedwiththeincreaseofI1]}-9andHOMA—IR.KEYWoRDS:mat
