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1、TRODAT-1脑显像在帕金森病诊断与分级中的应用中国医学影像技术2006年第22卷第7期ChinJMedImagingTechnol,2006,Vol22,No7?1O79?嚼核医学99Tcm—TRODAT一1SPECTimagingfordiagnosisandscalingofParkinson'sdiseaseDONGFeng,LIUXiao-hua,TANJian,ZHANGBen-shu.,SUNFeng.(1.DepartmentofNuclearMedicine,2.Departmentof
2、Neurology,TianjinMedicalUniversityGeneralHospital,n口njin300052.China)[Abstract]ObjectiveToinvestigatetheclinicalapplicationvalueinthediagnosisandscalingofParkinson'sdisease(PD)with"Tcm_TRODAT-1SPECTdopaminetransporter(DAT)imaging.MethodsFifty-eightPDpatien
3、ts(Hoehn&YahrscaleI一Ⅳ,UPDRSscore9—108)and13volunteerswererecruited.Theradiationratiosofstriatumanditssubregions,in—cludingtheputamenandcaudatenucleus,overthecerebellumwerecalculatedbysemi—quantityregionofinterest(R0I)tech—nique.Thefunctiondifferentiati
4、onofstriatumandputamenorcaudatenucleus,betweenthehealthyvolunteersanddifferentscaledPDpatientswerecompared.theDATvaluebetweencontralateralandipsilateraltosymptomsormoreaffectedlimbswascomparedaswel1.Therelationshipbetweentheradiationratiosofstriatum/cerebe
5、llumandUPDRSscorewasanalyzed.ResultsTheDATlevelofPDpatientsscaledI一Ⅳwasmorelowerthanthatofthehealthyvolunteers.Thereexitedneg—ativecorrelationbetweentheradiationratioandtheUPDRSscore:theDATlevelsofstriatumcontralateraltotheaffectedlimbwerelowerthanthoseofi
6、psilateralofPDpatientsscaledI一2.5.ForpatientsscaledⅢ一Ⅳ,neitherdifferencewasseenbetweenthetwosides,nordifferencebetweenthetwoscales.ForpatientsscaledI一2.5,theDATfunctionofputa—menandcaudatenucleuswerebothlowerthanthatofhealthyvolunteers,therealsoexiteddiffe
7、rencebetweenputamenandcaudatenucleus,morelOSSofDATfunctionwasseenintheputamennucleus.ForpatientsscaledⅢ一Ⅳ,bothputamenandcaudatenucleusfunctiondecreasedobviously,whilenodifferencebetweenthetwonucleus.Conclusion..Tcm-TRODAT-1SPECTbrainimagingishelpfulforthee
8、arlydiagnosisandscalingofPD.Theradiationratioofstriatum/cerebellumcanbeusedasasemi-quantitativestandardforthediagnosisandseverityevaluationofPD,itisalsoavaluablecomplementtothemonitoringofPDinadditiontoHoehn&
