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1、HER-2／neu、PCNA在人膀胱移行细胞癌中的表达及意义北京医学2008年第3O卷第9期HER一2/neu,PCNA在人膀胱移行细胞癌中的表达及意义胡杰彬1万光霞1蒋先镇2.论着.【摘要】目的探讨HER一2/neu,增殖细胞核抗J~.(PCNA)在人膀胱移行细胞癌(BTCC)@的表达及临床意义.方法采用免疫组化技术检测58例BTCC组织,22例正常膀胱组织中HER一2/neu和PCNA的表达,分析HER:2/neu,PCNA表达率水平与肿瘤病理分级,临床分期的相关性,以及两指标间的相关性.结
2、果HER-2/neu,PCNA在BTCC中的表达分别为53.4%,63.8%,明显高于正常膀胱黏膜.HER一2/neu在高分化,浅表性BTCC中的表达率分别为21.7%,29.O%,明显低于中低分化,浸润性BTCC.PCNA在高分化,表浅性BTCC中的表达率为30.4%,35.5%.明显低于中低分化,浸润性BTCC.HER一2/neu,PCNA在BTCC中的表达呈正相关.结论HER一2/neu促进BTCC的发生和发展.可作为诊断,评估恶性程度的指标.【关键词】膀胱移行细胞癌增殖细胞核抗原Expr
3、essionsandclinicalsignificanceofHER-2/neu,PCNAonhumanbladdertransitionalcellcancerHUJ一bin,WANGuang-xia,JIANGXian-zhen(DepartmentofUrology,CentralHospitalofXiangtan,Hunan411lOO)【Abstract】ObjectiveToinvestigatetheexpressionofHER-2/neu,PCNAinbladdertran
4、sitionalcel1cancer(BI℃C)andnormalbladdertissues,andtostudytheirclinicalsignificance.MethodsImmunohistochemicalmethodwasusedtodetecttheexpressionofHER一2/neu.PCNAin58casesofBTCCand22casesofnormalbladdertissues.Thein—vestigationincludedtherelationshipof
5、HER一2/nellandPCNAwitllBI℃Cinvariouspathologicalgradesandclinicalstages:whetherornottherewascorrelationbetweenHER一2,neuandPCNA.ResultsTheexpressionrateofHER一2,neuandPCNAinBTCCwas53.4%,63.8%respectively,whichwassignificantlyhigherthanthenormalbladderti
6、ssues.TheexpressionrateofHER一2/neuinwell-differentiatedandsuperficialBTCCWas21.7%and29.O%respectively.1owerthanpoody—differentiatedandinvasiveBTCC.TheexpressionrateofPCNAinwel1-differentiatedandsuperficialBTCCwas30.4%,35.5%respectively.1owerthanpoody
7、—differentiatedandinvasiveBTCC.SignificantpositivecorrelationofHER一2/neuandPCNAwasfoundinBTCC.ConclusionsHER-2/neumayplayanimportantroleinthecarcinogenesisandde—velopmentofBTCCandmaybecomeausefu1indextodiagnoseandevaluatethemalignancyofBTCC.【Keywords
8、】Bladdertransitionalcellcancer(BTCC)ProliferatingcellnuclearantigenCNA)HER一2/neu又名c—erbB一2.是与表达表皮生长因子受体(EGFR)I~癌基因以及病毒癌基因有很高的同源性序列的一种癌基因.在许多肿瘤中表达明显增多.HER一2/neu被异常激活后发生自身磷酸化.并磷酸化其他底物.引起下游的信号传导.最终导致细胞的增殖甚至癌变.HER一2/neu一直是研究的热点之一.国内尚未见其与膀胱移行细胞癌(bladdertr
