βcatenin、apc在膀胱移行细胞癌中的表达与其临床意义

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1、垒皇!塑垡proteinexpressiongroupandtheabnormalproteinexpressiongroupwere68．4and50．0months．accordingtolog-ranktest(xz=19．29，P=O．000)．Inbladdercarcinomaandnormalbladdertissue，thenormalproteinexpressionrateofp-cateninwas57．4％(50／87)and100％(15／15)，thedifferencewasstatisticallysignificant(x2=10．011，P=O．0

2、01)．Thenormalproteinexpressionratecorrelatedwellwiththebladdercarcinoma’Sgrades，stagesandrecurrencefrequency,andthenormalproteinexpressionratedecreasedwiththeimprovementofthebladdercarcinoma’Sgrades．stagesandrecurrencefrequency(P<0．05)．Nostatisticallysignificantdifferencesbetweenthenormalprotei

3、nexpressiongroupandtheabnormalproteinexpressiongroupwerenotedintermsofsex，age，sizenumber,lymphnodemetastasis，timeofprimaryrecurrence，growthpatternandtumorlocationwithrespecttotheproteinexpressionrate．Betweenprimarycancerandrecurrentcancer,thenormalproteinexpressionrateofp-cateninwas37．8％(14／37)

4、and72．0％(36／50)withstatisticallysignificantdifferences(Xz=110．153，P=0．001)．Kaplan—Meierrevealedthattheaveragelivingtimeintheabnormalproteinexpressiongroupof13-cateninwas48．7±1．5months，whichwaslowerthan67．5±4．0monthsinthenormalexpressiongroup，Themediansurvivaltimeofthenormalproteinexpressiongrou

5、pandtheabnormalproteinexpressiongroupwere67．3and46．5monthsaccordingtolog-ranktest(Xz=21．18，P=0．000)．ThecorrelationofnormalproteinexpressionofAPCandIB-catenininbladdercarcinomawasstatisticallysignificant(r=O．277，P=O．006)．ConclusionThenormalproteinexpressionrateofAPCinthebladdercarcinomawassignif

6、icantlylowerthanthatincontrolgroup，andthenormalproteinexpressionrateofAPCisrelatedcloselywiththebladdercarcinoma’Sgradesandstages．Thenormalproteinexpressionrateof13-catenininthebladdercarcinomawassignificantlylowerthanthatincontrolgroup，andthenormalproteinexpressionrateof13-cateninisrelatedclos

7、elywiththebladdercarcinoma’sgrades，stagesandrecurrenceV垒鱼!!!竺!——frequency．ThecorrelationofnormalproteinexpressionofAPCand13-catenininbladdercarcinomawassignificant．ThereislowrecurrencechanceinthenormalproteinexpressiongroupofIB-ca