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ID:11034980
大小:34.00 KB
页数:10页
时间:2018-07-09
《有机磷农药中毒患者肝肾功能变化探究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、有机磷农药中毒患者肝肾功能变化探究【摘要】目的探讨急性有机磷农药中毒患者血清肝肾功能的变化。方法对61例急性有机磷农药中毒患者于中毒后20h内抽取静脉血进行血清肝肾功能及胆碱脂酶(ChE)检测,并与54例治愈组和63例健康对照组进行比较。做统计学分析。结果急性有机磷农药中毒后轻度中毒患者ChE有明显降低(P<0.001);中度中毒总胆红素(TBIL)、直接胆红素(DBIL)、尿素氮(BUN)、天冬氨酸转氨酶(AST)有明显升高而总蛋白(TP)、尿酸(UA)、ChE有明显降低(P均<0.001);重度中毒TBIL
2、、DBIL、谷氨酸丙酮酸转氨酶(ALT)、AST、肌酐(Cr)、BUN均有升高明显而TP、UA、白蛋白(ALB)、ChE降低明显(P均<0.001),有7例心跳停止及6例呼吸肌麻痹各项指标变化最明显者7例死亡。结论观察血清肝肾功能的变化可以判断有机磷农药中毒患者的中毒程度及预后。【关键词】有机磷中毒;肝功能;肾功能;预后Thestudyonchangesofserumhepaticfunctionandrenalfunctioninpatientswithacuteorganophosphoruspestici
3、depoisoningLINYong-quan,RONGLi-hua.TheAffiliatedQingzhouHospitalofWeifangMedicalCollege,Shandong262500,China10【Abstract】ObjectiveToexplorethechangesofhepaticfunctionandrenalfunctioninpatientswithorganophosphoruspesticidepoisoning.MethodsBloodsimplesweretaken
4、formeasurementofserumhepaticfunction,renalfunctionandcholinesterase(ChE)of61caseswithacuteorganophosphoruspesticidepoisoningwereexaminatedwithin20hoursafterintoxication.Moreover,tocomparethechangeofhepaticfunctionandrenalfunctionbetweenrecoverygroup(n=61)and
5、controlgroup(n=65)individually.ResultsInmildpoisoningcases,ChEdecreasedobviously(P<0.001);inmoderatepoisoningcases,Serumtotalbilirubin(TBIL),directbilirubin(DBIL),bloodureanitrogen(BUN)andaspartateaminotransferase(AST)levelswereincreasedobviously,buttotalpro
6、tein(TP),uricacid(UA)andChElevelsweredecreasedobviously(allP<0.001);inseverepoisoningcases,TBIL,DBIL,glutamicpyruvictransaminase(ALT),AST,creatinine(Cr)andBUNlevelswereraisedobviously,TP,UA,Albumin(ALB),ChEweredecreasedobviously(allP<0.001).7of13caseswithcar
7、diacarrestorrespiratory10muscularparalysisinpoisoninggrouphadmostremarkablechangesoftheseserumindicesanddied.ConclusionToobservechangesofserumhepaticfunctionandrenalfunctioninpatientswithacuteorganophosphoruspoisoninghaveagreatvalueinjudgingthedegreeofpoison
8、ingorprognosis.【Keywords】Organophosphoruspoisoning;Hepaticfunction;Renalfunction;Prognosis急性有机磷农药中毒可引起多脏器损伤,特别是肝肾功能的损伤。为了解其临床意义,我们对61例急性有机磷农药中毒患者进行血清总胆红素(TBIL)、直接胆红素(DBIL)、白蛋白(ALB)、谷氨酸丙酮酸转氨酶(ALT
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