联合用药预防激素性股骨头坏死对血浆一氧化氮含量影响

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1、联合用药预防激素性股骨头坏死对血浆一氧化氮含量影响【摘要】目的观察联合用药预防激素性股骨头坏死对血浆NO含量的影响，探讨联合用药预防的作用机制。方法30只兔随机分成三组：对照组同期肌内注射生理盐水；激素组是给予糖皮质激素肌注；治疗组在给予同剂量糖皮质激素同时，每日使用血塞通、脂必妥和阿仑膦酸钠；观察股骨头组织学变化，用免疫组化技术检测血浆NO含量的变化。结果激素组股骨头软骨下骨小梁稀疏、断裂，脂肪细胞直径增大，空骨陷窝较多，血浆NO含量显著低于对照组；治疗组股骨头软骨下骨小梁结构较正常，血浆NO含量显著高于激素组。结论联合应用血塞通、脂必妥和阿

2、仑膦酸钠能预防和减缓激素性股骨头的发生，血浆NO含量升高是联合用药预防的作用途径之一。�【关键词】糖皮质激素；股骨头坏死；一氧化氮Effectofdrugspreventingsteroid-inducedosteonecrosisofthefemoralheadonthecontentofnitricoxideinplasmaCHENXiu-qin,LIJing-tian,ZOUJin-hui,etal.DepartmentofPhysiology,MedicalCollegeofShaoguanUniversity,Guangdong512

3、026,China8【Abstract】ObjectiveToobservetheeffectofdrugspreventingsteroid-inducedosteonecrosisofthefemoralheadonthecontentofnitricoxideinplasmainordertoinvestigatetheroleofthejointdruginthepreventionmechanism.MethodsThirtyrabbitsweredividedrandomlyinto3groups:groupA,guoupBandg

4、roupC.RabbitsingroupAwereinjectedwithnormalsaline;rabbitsingroupBweretreatedwithglucocorticoid;rabbitsingroupCweretreatedwithglucocorticoidasthatingroupB,andmeanwhile,orallyreceivedthepanaxnotoginsengsaponins,zhibituoandalenduonatefor8weeks.Histopathologicalstructureandtheco

5、ntentofnitricoxideinplasmawereobserved.ResultsThetrabeculaoffemoralheadoftheBgroupchangedthinnerandmoresparse,thebonemarrowcavitywithedemaandlargefattycellswerealsoobservedandthecontentofnitricoxideinplasmaofgroupBwassignificantlylowerthanthoseofgroupA.Thetrabeculaoffemoralh

6、eadoftheCgroupwasnormalandthecontentofnitricoxideinplasmaofgroupCwassignificantlyhigherthan8thoseofgroupB.ConclusionTheZhibituo,PanaxnotoginsengsaponinsandAlenduonatemaypreventsteroid-inducednecrosisoffemoralheadandtherisingofthecontentofnitricoxideinplasmawasoneofthewayofdr

7、ugspreventingsteroid-inducedosteonecrosisofthefemoralhead.�【Keywords】Glucocorticoid;Necrosisoffemoral;Nitricoxide激素性股骨头坏死的发病率占非创伤性股骨头坏死首位，并有增高趋势，已引起广泛的重视。但目前关于激素性股骨头缺血性坏死的研究多集中在治疗已形成的坏死，对在使用激素过程中如何预防股骨头坏死，研究较少[1]。本课题组在建立激素性股骨头坏死动物模型的过程中，采用血塞通、脂必妥和阿仑膦酸钠联合用药进行预防性治疗，结果证实联合用药预防可

8、提高股骨头血流量，改善骨组织结构和血液流变学指标，预防或减缓激素性股骨头坏死[2，3]。本实验是进一步观察联合用药对血浆一氧化氮(nitricoxid