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1、粒细胞集落刺激因子的神经保护作用机制l床儿科杂志第29卷第4期2011年4月JClinPediatrVo1.29No.4Apr.2011[16]KonstantinouGN,GiaviS,KalobatsouA,eto1.Consumptionofheat—treatedeggbychildrenallergicorsensitizedtoeggcanaffectthenaturalcourseofeggallergy:hypothesis—generatingobservations[J1.JAllergyClinImmunol,2008,122(
2、2):414—415.[17]Lemon—MuleH,SampsonHA,SichererSH,eta1.Immunologicchangesinchildrenwitheggallergyingestingextensivelyheatedegg[J].JAllergyClinImmunol,2008,122(5):977—983.[18]SavageJH,MatsuiEC,SkripakJM,eta1.Thenaturalhistoryofeggallergy[J].JAllergyClinImmunol,2007,120(6):1413一doi
3、:10.3969/j.issn.1000—3606.2011.04.027?389?1417.[19]Boyano—MartinezT,Garcia—AraC,Diaz-PenaJM,eta1.Predic—tionoftoleranceonthebasisofquantificationofeggwhite-specificIgEantibodiesinchildrenwitheggallergy[J].JAllergyClinImmunol,2002,110(2):304—309.[20]AndoH,MoverareR,KondoY,eto1.U
4、tilityofovomucoid-specificIgEconcentrationsinpredictingsymptomaticeggallergy[J1.JAllergyClinImmunol,2008,122(3):583—588.(收稿日期:2010—07—26)粒细胞集落刺激因子的神经保护作用机制王洁洁综述徐家丽审校安徽蚌埠医学院第一附属医院儿科(安徽蚌埠233000)摘要:粒细胞集落刺激因子(granulocytecolony—stimulatingfactor,G—CSF)是一种造血生长因子,可促进造血干细胞的增殖,分化及生存,在临床
5、上广泛应用于治疗粒细胞减少症.近来越来越多的实验表明,G.CSF对神经系统具有明显的保护作用.文章阐述了G—CSF的神经保护作用机制.瞄床,f.科杂志,2011,29):389-3921关键词:粒细胞集落刺激因子;缺氧缺血性脑损伤;神经保护作用中图分类号:R725文献标志码:A文章编号:1000—3606(2011)04—0389—04Theneuroprotectiveeffectofgranulocytecolony-stimulatingfactorReviewer:WANGJie-jie,Reviser:XUJia-li(Department
6、ofPediatrics,TheFirstAffiliatedHospitalofBengbuMedicalc0,Bengbu233000,Anhui,China)Abstract:Granuloeytecolony—stimulatingfactor(G—CSF)wasidentifiedasahematogoieticgrowthfactor.Itpromotesthesurvival,proliferation,anddifferentiationofhematopoieticprogenitorcells.G—CSFiswidelyemplo
7、yedfortreatmentofneutropenia.Recently,moreandmoreexperimentalresultshaveshownthatG—CSFhasaroleinprotectionofthenervoussystem.ThisreviewfocusesontheneuroproteetivepropertiesofG—CSF.(_,ClinPediatr,2011,29(4):389-392)Keywords:granuloeytecolony—stimulatingfactor;hypoxic—isehemicbra
8、ininjury;neuroprotection粒细胞集落刺激因子(granuloeytecolony—st
