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1、U50，488H对大鼠离体心脏的抗心律失常作用784?研究原着-第四军医大学(一JFourthMilMedUniv)2006;27(9)http://joumal,fmmu.edu.cnU50,488H对大鼠离体心脏的抗心律失常作用文章编号:1000-2790(2006)09-0784-04漆伟,魏宝珍,王跃民,裴建明(第四军医大学:'学员旅八队,基础部生理学教研室,陕西西安710033)AntiarrhythmiceffectofU50.488Honisolatedratheart/nvitroQIWei',WEIBao?Zhen,WANGYue—Min
2、,PEIJian?'Team8,CadetBrigade,DepartmentofPhysiology,SchoolofBasicMedicine,FourthMilitaryMedicalUniversity,Xi'an7loo33.China【Abstract】AIM:ToinvestigatetheeffectofU50,488H(aselectiveK—opioidreceptoragonist)andnoradrenalin(NE,anadrenergicreceptoragonist)onventriculararrhythmiasinduce
3、dbymyocardialischemiaandreperfusioninratsinvitro.METHODS:Ratswererandomlydividedinto5groups(7ratsineachgroup),i.e.,normalcontrolgroup,ischemia/reperfusiongroup(I/R),US0,488H+I/Rgroup,NE+I/Rgroup,U50,488H+NE+I/Rgroup.TheisolatedheartwasperfusedbyusingLangendorffequipmentandthefront
4、branchofcoronaryarterywasligatedfor20min,andthentheperfusionwasresumedfor20mintoengendertheI/Rcondition.US0.488H(5×10一.mol/L)andNE(1×10mol/L,wereusedtointerferetheeffectsduringmyocardialischemiaandreperfusion.Heartrate(HR),arterialbloodpressure(ABP),leftventricularpressure(LVP),ca
5、rdiacfunction(±dp/dtmax),rateofventriculartachycardia(VT)andventricularfibrillation(VF)weredeterminedinrats.RESULTS:①Everyindexoftheheartfunctionsdecreasedsignificantly,andHRincreasedaftermyocardialischemia.Withmyocardialreperfusion,theconditionwasimprovedalittle.ComparedtlII/Rgro
6、up,HRdecreasedsignificantlywithUS0,488Hadministration(P<0.05).②ComparedwithnormalcontrolgroupandI/Rgroup,theincidenceofventriculararrhyth?miasandarrhythmiaSCOrewereenhancedinI/R+NEgroup(P<O.01).However,itshowedthatnotonlytheincidenceofVTandVFSCOreduringmyocardialischemiaandr
7、eperfusionandventricular~rrhythmiasandarrhythmiaSCOreofI/Rgroup,butalsoventriculararrhythmiasandarrhythmiaSCOreofI/R+NEgroupdecreasedsignificantlytlIadministrationofU50.488H(P<0.01).CONCLUSION:K?opioidreceptoragonistU50,488HantagonizesthearrhythmiasinducedbyNEduringmyocar.收稿日期:
8、2005?10—19;接受日期:2005.12-07基金项目:国家
