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1、CTOP与CHOP方案治疗外周T细胞淋巴瘤的疗效比较?638?中国肿瘤临床2006年第33卷第11期CTOP与CHOP方案治疗外周T细胞淋巴瘤的疗效比较摘要目的:比较含吡喃阿霉素(THP)的CTOP方案与含阿霉素(ADM)的CHOP方案治疗外周T细胞性非霍奇金氏淋巴瘤一非特异性(FrrCL_U)的疗效和不良反应.方法:采用两种方案治疗FrrCL—U患者共130例,THP组49例,ADM组81例.结果:两组患者临床特征指标相似(P>0.05).可评价疗效129例,两组有效率分别为71.6%和72.8%,CR率分别为
2、43.2%和39.5%(P>0.05).骨髓抑制,胃肠道反应,脱发为主要不良反应.Ⅲ～Ⅳ度白细胞降低,血小板和血红蛋白降低发生率两组无明显差异;脱发ADM组高于THP组(31.1%:14.0%,P<0.001);ADM组心脏毒性稍高于THP组(11.1%%:6.1%,0.522).中位随访24个月(1～88个月),两组预计5年生存率分别为22.0%和42.2%(P<0.01).结论:采用含THP的CTOP方案治疗FrrCL-U疗效较好,毒性较低,远期生存率较高,值得临床进一步研究.关键词外周T细胞性淋
3、巴瘤吡喃阿霉素阿霉素中图分类号:R733.1文献标识码:A文章编号:100O一8179(2006)11一o638—03ComparisonofTherapeuticEffectsofCTOPandCHOPRegimenonUnspecifiedPeripheralT-cellLymphomaHuangHuiqiangPengYulongPanZhanheetalDepartmentofMedicalOncology,CancerCenter,SunYat-senUniversity,Guangzhou,Guangdon
4、gAbstractObjective:TocomparetheefficacyandtoxicityofCTOPwithTHP1andCHOPinthetreatmentofunspecifiedperipheralT-celllymphoma(PTCL—U).Methods:Onehundredandthirtypa-tientswithPTCL—Uweretreatedwithcombinedchemotherapy,includingCTOPandCHOP,fromJan-uary1997toDecember20
5、03intheCancerCenter,amongwhich49weretreatedbyCTOPand81byCHOPregimen.Therateofresponse,toxicityandlong—termsurvivalforthetworegimenswereana-lyzedretrospectively.Results:TheclinicalcharacteristicsofthetwogroupsweresimilarfP>0.05).Atotalof129patientswereeligible
6、.TheresponserateforCHOPandCTOPwas71.6%and72.8%.re-spectively'P>0.05)andtheCRratewas43.2%and39.5%,respectively'P>0.05).Majortoxicitywasmyelosuppression,GItoxicityandalopecia.TherewasnodifferencebetweenthetwogroupsingradeⅢ～IVtoxicityinneutropenia.thrombocyto
7、peniaandanemia.IncidenceofalopeciawashigherintheCHOPgroup(31.1%VS.14.0%,P=O.ooo).AhhoughcardiotoxicitywashighinCHOPgroup(11.1%VS.6.1%),nostatisticaldifferencebetweenthetwogroupswasconfirmed(P0.522).Medianfollow—upwas24months(rangedfrom1to88months).The5-yearovera
8、llsurvivalrateforCHOPandCTOPgroupwas22.0%and44.2%,respectively<0.01).Conclusions:THPintheCTOPregimenmaybemoreeffectiveonPTCL-Uwithlowertoxicityandbetterlongtermsur
