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1、星状神经节阻滞联合舍曲林治疗原发性早泄【摘要】目的:观察舍曲林联合星状神经节阻滞(SGB)治疗原发性早泄(PE)的近期疗效和安全性。方法:原发性PE患者50例，随机分为两组，每组25例。药物组每日口服舍曲林50mg；联合组（舍曲林+SGB组）每日口服舍曲林50mg，同时每周两次SGB，两组疗程共4w。评价治疗前后阴道内射精潜伏期(IELT)的变化；同时以问卷形式评价治疗前后射精控制感、性满意度、焦虑程度、人际关系紧张程度的变化；并进行组间对比。结果:与治疗前相比，治疗后两组IELT均有明显延长,药物组和联合组分别从治疗前的(0.75±0.36)分和(0.77±0.29)分，增加到治疗后的(2.
2、63±1.66)分和(2.71±1.57)分；治疗前后IELT的差异有显著性，而组间IELT差异无显著性。两组治疗后射精控制感、性满意度、焦虑程度、人际关系紧张程度都有明显改善。联合组的射精控制感和性满意度优于药物组，差异具有显著性。结论:SGB与舍曲林联合治疗，可以有效地延长IELT，其效果与单纯舍曲林治疗无差异。但是，联合治疗可以更好地提高患者对射精的控制能力和性满意度。因此，SGB能否作为一种有效治疗原发性PE的手段，还有待于进一步临床验证。【关键词】原发性早泄;13星状神经节阻滞；阴道内射精潜伏期Sertralinecombinedwithstellateganglionblockin
3、treatmentofprematureejaculationZHANGGuoxi�1，WANGXiaofeng�1,BAIWenjun�1，YANGJunjun�21DepartmentofUrology，People’sHospital,PekingUniversity,Peking100044,China2DepartmentofAnesthesiology，People’sHospital,PekingUniversity,Peking100044,China【Abstract】Objectives:Toinvestigateontheefficacyandsafetyofsertra
4、linecombinedwithstellateganglionblock（SGB）intreatmentofprematureejaculation（PE).Methods：Atotalof50patientswithPEwererandomlyenrolledinto2groups，eachincluding25members.Overa4-weektreatmentperiod,thesertralinegrouptooksertraline50mgonceaday；andthecombinedgroup（SertralinewithSGB）weregivenbothsertraline
5、50mgonceadayaswellasSGBtherapytwiceaweek.AllpatientsfinishedPEquestionnaireswhichinclude4items（perceivedcontroloverejaculation,personal13distressrelatedtoejaculation,satisfactionwithsexualintercourse,interpersonaldifficultyrelatedtoejaculation）,andestimatedintravaginalejaculationlatencytime(IELT)was
6、recorded.Results：Aftertreatment,IELTincreasedforbothgroup,frombaseline（4.34±2.12）to（3.65±2.23）mininsertralinegroup,andfrom（6.23±2.66）,to（5.22±3.22）incombinedgroup,respectively.Moreover,theimprovementsofIELTandPROachievedweremoresatisfiedincombinedgroupthaninsertralinegroup.Thedifferencesweresignific
7、ant.Conclusions：ThecombinationofsertralinewithSGBwasmoreeffectiveintreatmentofPEthansertralinemonotherapy,whichindicatedthatthecombinedtheropymayprovideanewwayfortreatmentofPE.【Keywords】Lifelongpremat
