current medical research programs

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1、CurrentMedicalResearchPrograms HypothermicReperfusionafterIschemiaImprovesVentricularMyocyteContractilityandIntracellularCa2+ Dynamics Anenergy-sparingeffectofhypothermiahasbeendescribed,suchthatloweringthetemperaturemayleadtoincreasesincardiacworkwithoutincreases

2、inenergycost.Wehaverecentlyreportedimprovedmyocardialfunctionwithhypothermiafollowingresuscitationfromcardiacarrest.Inthepresent investigation,wehypothesizedthatreductionsinreperfusiontemperaturefrom37°C to 30°C after10minutesofischemiawouldminimizethedecreasesinm

3、yocytecontractilityandintracellularCa2+transients. Results: Hypothermicreperfusionfollowingischemiaimproved myocytecontractility. Increasedmyocyte intracellularCa2+ dynamicsduringhypothermiaaccountedforthegreatercellcontractility. HypothermiaImprovesVentricularMyo

4、cyteSensitivitytoExtracellular Ca2+Wehavepreviouslyreportedthathypothermiaminimizestheimpairmentofmyocytecontractilityfollowingischemia.Inthepresent study, weinvestigatedthemechanismsaccountingforthesereducedimpairmentsincontractility.Wehypothesizedthathypothermia

5、wouldincreasemyocyte sensitivity to extracellularCa2+ underconditionsofnormalperfusionandfollowingreperfusionafterischemia. Results: HypothermiaincreasedmyocytesensitivitytoextracellularCa2+ content,andthisaccountedforgreatercontractility. Hypothermicreperfusionaf

6、terischemiamaintainedgreaterresponsivenessofmyocytecontractilitytoextracellularCa2+ content,incomparisontonormothermicreperfusion.  Current-BasedImpedanceCompensationOutperformedDuration-BasedTechniqueinDefibrillationEfficacyinaHighImpedancePigModelTransthoracicim

7、pedance(TI)fordefibrillationvarieswidelyinpatientswithamedianvalueofapproximately95-100ohms.Highimpedancepatientsaremoredifficulttodefibrillate.Themoderngenerationofexternaldefibrillatorsthereforeadjustsdefibrillationoutputbasedonpatientimpedancemeasurementpriorto

8、shockdelivery(impedancecompensation).Commercialexternaldefibrillatorsusedifferentimpedancecompensationmethods(ICM).DefibrillatorA(DefA,rectilinearbiphas