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1、CurrentHypothesesandResearchMilestonesinAlzheimer’sDiseaseRicardoB.Maccioni•GeorgePerryEditorsCurrentHypothesesandResearchMilestonesinAlzheimer’sDiseaseEditorsRicardoB.MaccioniGeorgePerryMind/BrainProgramoftheInternationalCollegeofSciencesCenterofBiomedicineandUniversityofTexasatSa
2、nAntonioUniversityofChileSanAntonio,Texas78249-0661Santiago,ChileUSAandUniversityofMiamiSchoolofMedicineMiami,FloridaUSAISBN:978-0-387-87994-9e-ISBN:978-0-387-87995-6DOI:10.1007/978-0-387-87995-6LibraryofCongressControlNumber:2008942056©SpringerScience+BusinessMedia,LLC2009Allright
3、sreserved.Thisworkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewrittenpermissionofthepublisher(SpringerScience+BusinessMedia,LLC,233SpringStreet,NewYork,NY10013,USA),exceptforbriefexcerptsinconnectionwithreviewsorscholarlyanalysis.Useinconnectionwithanyformofinformationstorag
4、eandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodologynowknownorhereafterdevelopedisforbidden.Theuseinthispublicationoftradenames,trademarks,servicemarks,andsimilarterms,eveniftheyarenotidentifiedassuch,isnottobetakenasanexpressionofopinionastowhethe
5、rornottheyaresubjecttoproprietaryrights.Printedonacid-freepaperspringer.comPrefaceAlmostfourdecadesofincreasinglyfasterandmoreintensiveresearchonAlzheimer’sdisease(AD)havebroughtmajoradvancesinourunderstandingofitspathogenesis,improvedtoolsfordiagnosis,andstrategiesforitstreatment.
6、Thisresearchhasshownusthatexploringthefactorsleadingtocognitiveimpairmentismiredwithelusivegoalsandunexpectedleadstowardthemechanismsresponsibleforthispathology.Thiscomplex,yetfruitfulprocesshasallowedustocontributetobuildingasolidfoundationofknowledgeintheneurosciences,totacklethe
7、biologicalbasisofAD,andrelatedneurologicaldisorders.Thisbookcontains20seminalchaptersbyauthorswithdifferentviewsthatinamultidisciplinaryapproachfocusonthemainissuesofneuroanatomical,neuropatho-logical,neuropsychological,neurological,andmolecularbiologicalaspectsofAD.Theideaforthisc
8、ollectionaroseduringthepre
