麻疹(英文)-精品ppt课件

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1、麻　疹MEASLES重庆医科大学儿童医院DIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGY1MEASLESKeypointsDIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYAcuterespiratoryinfectiousdiseasecausedbymeaslesvirusclinicalfeature:Fever,Cough,Runnynose,Conjunctivitis,ExanthemSpecificsign:Koplik’sSpots(akindofenanthem)2DIVISI

2、ONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYClassification:ARNAvirusGenus:morbillivirusFamily:paramyxoviridaeSerotype:OnlyoneLocation:Nasopharyngealsecretions,Blood,UrineofpatientsPathogen3PathogenDIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYmeaslesvirus4DIVISIONOFINFECTIOUSDISEASEANDGASTROENTER

3、OLOGYEpidemiologyInfectioussources：MeaslespatientsinacutestageRoutesoftransmission：DropletsprayPopulationsusceptibility：4.Epidemicfeatures：Itissusceptibletoallthepeoplewithoutinfectionorinoculation.Theageofpeakincidencewas6monthsto5yearsold.Theincidenceofbabyunder6mislower.5DIVISIONOFINFECTIO

4、USDISEASEANDGASTROENTEROLOGYRoutesoftransmissionEpidemiologyDropletspray6DIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYPriortotheuseofvaccineAftertheuseofvaccineMorbidity(1/100000)Majorepidemics:500-1000Mildepidemics:4009.5in1990PeakseasonInwinterandspringInanytimeofayearEpidemiccycleMajorepi

5、demicsappearby2-4yrintervalsEpidemiccycledisappeared,SporadiccasesincreasedAge6m-5y(98%<10y)Below6mandabove5yClinicalmanifestationsTypicalcasesseveremanifestationsmorecomplicationshighmortalityAtypicalcasesmildmanifestationslesscomplicationsrarelydeathEpidemiologyEpidemicFeatures789DIVISIONOF

6、INFECTIOUSDISEASEANDGASTROENTEROLOGY0003MeaslesVaccineInoculationinwholeChina(1968)EpidemiologyMeaslescasesofin-patientsinCHCUMS10DIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYPathophysiology11RespiratoryepitheliumregionallymphnodesFirstviremiaMonocytes/MacrophageSecondviremiaRespiratorytract

7、,conjunctiva,skin,etcViruseliminationMeaslesvirusPathophysiology1.Incubationperiod10-14days2.Prodromalperiod3-4days3.Apparentmanifestationperiod3-5days4.Convalescentperiod3-5days12DIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYPathology13Multi